When we compared 5-HT1A, main presynaptic regulator of 5-HT, we found that in humans was highly expressed in cortex and lowly in other areas, conversely in mice the expression profile is similar between areas and in dendrogram was separated as only one but been similar in isocortex
Intraventricular administration of Al-maltolate to rabbits developed widespread neurofibrillary degeneration involving pyramidal neurons of the isocortex
and allocortex, projection neurons of the diencephalon, and nerve cells of the brain stem and spinal cord (37).
It is a conjecture that has inspired our research for more than the last ten years, which has come to be called the isocortex
conjecture, stated in (1):