isoflavone


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Related to isoflavone: Soy isoflavones

isoflavone

[¦ī·sō′fla‚vōn]
(biochemistry)
C15H10O2 A colorless, crystalline ketone, occurring in many plants, generally in the form of a hydroxy derivative.
References in periodicals archive ?
Lim et al., "Isoflavone metabolites and their in vitro dual functions: They can act as an estrogenic agonist or antagonist depending on the estrogen concentration," Journal of Steroid Biochemistry and Molecular Biology, vol.
At the end of the trial, participants who received soy isoflavones had lower insulin and markers of insulin resistance, free androgens, and serum triglycerides in comparison with those who received a placebo.
Table 1: Dietary sources of high isoflavone containing soy foods Dietary source Total isoflavones mg/100g Soy beans dry roasted 148 Soy beans boiled 65 Soybeans canned 52.8 Miso 41.5 Tempeh 35-72 Tofu 22-34 Silken tofu 18 Edamame (cooked) 17.9 Soy and linseed bread 14.7 Smoked tofu 13.1 Soy milk 7-10
Soy isoflavones are naturally occurring, plant-based estrogens found in the soybean plant.
The soy isoflavone genistein induces estrogen synthesis in an extragonadal pathway.
To test the theory, 200 women in early menopause were either given a daily supplement containing soy protein with 66 milligrams of isoflavones, or one only containing soy protein for six months.
Results of Kruskal-Wallis test between the delta AV lesion values obtained in 5 groups were statistically significant (pless than 0.05), (Table 5) and differences between groups as measured by Mann-Whitney test showed that mean delta value of 160 isoflavone group was significantly superior (pless than 0.05) to that of placebo, 40 mg of isoflavones, isoflavone 80 mg, and 120 mg isoflavones, whereas among other groups it was not significant (pgreater than 0.05), (Table 6).
As shown in Table 1, cell viability in [MPP.sup.+] group was lower than in control (P < 0.05), isoflavone + [MPP.sup.+] (P < 0.01), Z-YVAD-CHO + [MPP.sup.+], and Z-DEVD-CHO + [MPP.sup.+] groups (P < 0.05).
Despite previous reports that soy isoflavones have deleterious effects, they still are often used by postmenopausal women as an alternative to hormone therapy, according to study author, D.
Since 2000,13 studies have given a placebo or a daily isoflavone supplement to a total of nearly 1,200 menopausal women in six countries for six weeks to one year.
Total isoflavone content (TIC) gradually increased from 666.1 (control) to 755.2 mg/kg (10 kGy) (Table 1).