Lim et al., "Isoflavone
metabolites and their in vitro dual functions: They can act as an estrogenic agonist or antagonist depending on the estrogen concentration," Journal of Steroid Biochemistry and Molecular Biology, vol.
At the end of the trial, participants who received soy isoflavones
had lower insulin and markers of insulin resistance, free androgens, and serum triglycerides in comparison with those who received a placebo.
Table 1: Dietary sources of high isoflavone
containing soy foods Dietary source Total isoflavones
mg/100g Soy beans dry roasted 148 Soy beans boiled 65 Soybeans canned 52.8 Miso 41.5 Tempeh 35-72 Tofu 22-34 Silken tofu 18 Edamame (cooked) 17.9 Soy and linseed bread 14.7 Smoked tofu 13.1 Soy milk 7-10
are naturally occurring, plant-based estrogens found in the soybean plant.
The soy isoflavone
genistein induces estrogen synthesis in an extragonadal pathway.
To test the theory, 200 women in early menopause were either given a daily supplement containing soy protein with 66 milligrams of isoflavones
, or one only containing soy protein for six months.
Results of Kruskal-Wallis test between the delta AV lesion values obtained in 5 groups were statistically significant (pless than 0.05), (Table 5) and differences between groups as measured by Mann-Whitney test showed that mean delta value of 160 isoflavone
group was significantly superior (pless than 0.05) to that of placebo, 40 mg of isoflavones
80 mg, and 120 mg isoflavones
, whereas among other groups it was not significant (pgreater than 0.05), (Table 6).
As shown in Table 1, cell viability in [MPP.sup.+] group was lower than in control (P < 0.05), isoflavone
+ [MPP.sup.+] (P < 0.01), Z-YVAD-CHO + [MPP.sup.+], and Z-DEVD-CHO + [MPP.sup.+] groups (P < 0.05).
Keywords: Breast cancer, Docetaxel, Soy isoflavone
Despite previous reports that soy isoflavones
have deleterious effects, they still are often used by postmenopausal women as an alternative to hormone therapy, according to study author, D.
Since 2000,13 studies have given a placebo or a daily isoflavone
supplement to a total of nearly 1,200 menopausal women in six countries for six weeks to one year.
content (TIC) gradually increased from 666.1 (control) to 755.2 mg/kg (10 kGy) (Table 1).