isohemagglutinin


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isohemagglutinin

[¦ī·sō‚hē·mə′glüt·ən·ən]
(immunology)
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Antibody titrations are important in antenatal evaluations, antibody identifications, separating multiple antibodies, and ABO isohemagglutinin testing.
Recipients of major ABO-incompatible stem cell grafts possess isohemagglutinins directed against donor RBCs and are at risk for immediate or delayed hemolysis of donor RBCs and destruction of donor erythroid precursor cells, causing delayed erythroid engraftment and pure red cell aplasia (PRCA).
However, vigilant monitoring of patients at risk during the first two weeks posttransplant, including daily complete blood count and lactate dehydrogenase (LDH) and screening for donor isohemagglutinins, is recommended.