isoimmunization

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isoimmunization

[¦ī·sō‚im·yə·nə′zā·shən]
(immunology)
Immunization of an individual by the introduction of antigens from another individual of the same species.
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Associated with pregnancy in a grand multipara, there is an increased risk of abortion, malnutrition, anemia, multiple pregnancy, Rhesus isoimmunisation, antepartum haemorrhage and preterm labour.3 Complications like diabetes, hypertension, malpresentations, cephalopelvic disproportions, uterine rupture, postpartum hemorrhage and puerperal complications are also more frequently encountered.4,5,6 The fetus/neonate of the grand multipara is also at a higher risk of low birth weight, preterm birth and congenital malformations.7,8 Studies done in a developed country with satisfactory healthcare services, suggest that grand multi-parity should not be considered dangerous as such, instead risk assessment should be based on the past and present history and not on the basis of parity only9.
The local practice of replacement without documenting response should be avoided, as such practices may accelerate isoimmunisation. The major emphasis is to restrict this period and proceed to specific curative interventions as rapidly as necessary.
While effective in replacing the volume of blood loss, the procedure introduces several risk factors including transmission of viral agents, specifically human immunodeficiency virus (HIV) and hepatitis, insufficient platelet count, isoimmunisation, and possible transfusion reactions (Spain, Miller, Bergamini, Montgomery, & Richardson, 1997).