isoniazid

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isoniazid

isoniazid (īˌsōnīˈəzĭd), drug used to treat tuberculosis. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. The drug inhibits or kills the tubercle bacilli that cause the disease. It is usually given together with some other antituberculosis drug such as streptomycin or para-aminosalicylic acid to prevent emergence of drug resistant organisms (see drug resistance). To prevent development of tuberculosis in individuals who have a positive reaction to a tuberculin skin test, isoniazid is given alone. Side effects are seen only with very high doses.
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isoniazid

[‚ī·sə′nī·ə·zəd]
(pharmacology)
C6H7N3O A drug used as a tuberculostatic. Also known as isonicotinic acid hydrazide.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Isoniazide prophylaxis therapy (IPT) in contacts would not only improve individual clinical management but would aid to reduce the burden of disease in the community, improve clinical research for the prevention and treatment of the disease, and allow greater scope of diagnostics and case management in RNTCP.
The molecular basis of resistance to isoniazide, rifampicin, and pyrazinamide in Mycobacterium tuberculosis.
Multi-drug resistance to antituberculous medicine (defined as the resistance, at least, to isoniazide and rifampicine) is widely accepted as a threat against the control of tuberculosis (Tb) in various parts of the world.
INH, isoniazide; SM, streptomycin; RIF, rifampin; EMB, ethambutol; MDR, multidrug resistant
Molecular genetics assay for identification of resistance to rifampicin and/or isoniazide of the mycobacterium tuberculosis complex.
Except shortage of streptomycin, all of the health facilities had the recommended anti-TB drugs, namely, rifampicine, isoniazide pyrazinamide, and ethambutol, in the stock adequately during study period.