isoniazid

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isoniazid

(ī'sōnī`əzĭd), drug used to treat tuberculosistuberculosis
(TB), contagious, wasting disease caused by any of several mycobacteria. The most common form of the disease is tuberculosis of the lungs (pulmonary consumption, or phthisis), but the intestines, bones and joints, the skin, and the genitourinary, lymphatic, and
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. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. The drug inhibits or kills the tubercle bacilli that cause the disease. It is usually given together with some other antituberculosis drug such as streptomycinstreptomycin
, antibiotic produced by soil bacteria of the genus Streptomyces and active against both gram-positive and gram-negative bacteria (see Gram's stain), including species resistant to other antibiotics, e.g.
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 or para-aminosalicylic acid to prevent emergence of drug resistant organisms (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
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). To prevent development of tuberculosis in individuals who have a positive reaction to a tuberculin skin test, isoniazid is given alone. Side effects are seen only with very high doses.

isoniazid

[‚ī·sə′nī·ə·zəd]
(pharmacology)
C6H7N3O A drug used as a tuberculostatic. Also known as isonicotinic acid hydrazide.
References in periodicals archive ?
Isoniazide prophylaxis therapy (IPT) in contacts would not only improve individual clinical management but would aid to reduce the burden of disease in the community, improve clinical research for the prevention and treatment of the disease, and allow greater scope of diagnostics and case management in RNTCP.
He was initially treated with isoniazide, rifampicine, pirzinamide and etambutol, medicine that was suspended to receive treatment at home based on herbs recommended by a healer from the community.
17-217166, rifampicin 150 mg, isoniazide 75 mg, pyrazinamide 400 mg, compressed, oral ft 103674.
8 45 F Isoniazide, Diclofenac Erythema multiforme sodium, Ibuprofen, with oral erosions Ketorolac, Etoricoxib 9 36 F Acetaminophen, Mefenamic Urticaria acid, Tranexamic acid, Ketorolac, Ranitidine 10 67 F Acetaminophen, Ranitidine DRESS Diclofenac sodium, Exfoliative Alendronate dermatitis Serial Co-morbidity Antinuclear Antibody No Profile 1 None Negative 2 None Anti-PCNA antibody positive 3 None Negative 4 None Negative 5 Chronic hip and knee Anti-dsDNA, joint pain, Lupus antinucleosome, nephritis antihistone,, anti-U1RNP and anti-Ku antibodies positive 6 ?
Molecular genetics assay for identification of resistance to rifampicin and/or isoniazide of the mycobacterium tuberculosis complex.