isoproterenol

(redirected from Isoprenaline)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to Isoprenaline: propranolol, atropine

isoproterenol

[‚ī·sə‚prōd·ə′rē‚nȯl]
(pharmacology)
C11H17NO3 A sympathomimetic amine used as a bronchodilator.
References in periodicals archive ?
Isoprenaline, Myocardial infarction, Frankincense, I3-irradiation, Cardiac marker enzymes.
In some studies with hiPSC-CMs, the effects of isoprenaline (changes in beating frequency and APD) were checked and responses similar to those in native cardiomyocytes were shown [8].
Calcium gluconate and isoprenaline were infused and the blood pressure, after settling at 80/60, gradually rose, at first to a systolic of 90 mm.Hg, then 95 mm.Hg and finally 110 mm.Hg.
Antioxidant effect of Garcinia indica fruit extract against isoprenaline hydrochloride induced myocardial necrosis in rats.
Normal: normal control; ISO: model group only injected with isoprenaline; POS: positive control (propranolol, 10mg/kg); Diosgenin L, Diosgenin M, and Diosgenin H: orally given diosgenin 20, 40, and 80 mg/kg of low, medium and high dose, respectively, after ISO injection; DN extract: orally given Dioscorea nipponica extract (500 mg/kg), after ISO injection.
[sz]-adrenoceptors ([sz]-ARs), comprising [sz]1, [sz]2, and [sz]3 subtypes, have been reported to play a critical regulatory role in blood vessel endothelial cells.[sup][1] [sz]-AR stimulation can promote angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF), a crucial angiogenic protein.[sup][2] Isoprenaline (ISO; a synthetic catecholamine and [sz]-adrenergic agonist) has been shown to increase VEGF-A expression and VEGF receptor-2 (VEGFR-2) activity in hemangioma-derived endothelial cells.[sup][3] Similarly, ISO promotes angiogenesis in Matrigel cultures of human umbilical vein endothelial cells (HUVECs);[sup][4] however, the underlying mechanism remains to be clarified.
On rats, atria contraction was evaluated by screening the effects of isoprenaline, acetylcholine, propranolol and atropine.
All the studies were done on adult male rats weighing between 200-340 grams and experimental model of heart failure was created either by ligation of the coronary artery or was induced by isoprenaline (ISO).
Isoprenaline inhibitory CRCs: The relaxant graphs for isoprenaline were built against carbachol-induced contractions in trachea of guinea-pig in the lack and existence of the extract.
A well known example is that of bronchodilator isoprenaline (isoproterenol) in which 3-OH group replacement with other bioisosteric group like 3-CH 2 OH, resulting salbutamol (albuterol), selective Beta-2 agonist, a well known antiasthamatic drug, by 3-NHSO 2 CH 3 , resulting soterenol and by 3-NHCONH 2 , resulting carbuterol [42-43].
However, acute treatment with the anticholinergic agent atropine and the adrenergic agonist isoprenaline (Iso) may be warranted.
The relaxant effects of isoprenaline are impaired in tracheal smooth muscle isolated from B.