isoprostanes

[‚ī·sō′prä‚stānz]

(biochemistry)

A class of natural products that are isomeric with prostaglandins but are formed in vivo by the nonenzymatic, free-radical oxygenation of arachidonic acid.

References in periodicals archive ?

Isoprostanes, the stable end products of peroxidation of arachidonic acid, are widely accepted as reliable indicators of oxidative stress in vivo (1, 2).

Isoprostane measurement in plasma and urine by liquid chromatography--mass spectrometry with one-step sample preparation

2] isoprostanes of all study participants and also had very low concentrations of urinary [gamma]-CEHC, possibly reflecting a low dietary intake of [gamma]-tocopherol.

Assessment of tocopherol metabolism and oxidative stress in familial hypobetalipoproteinemia

The commonly studied markers are products of lipid peroxidation [such as malondialdehyde (MDA), 4-hydroxynonenal, and isoprostanes (3)], oxidized amino acidic residues (such as cystine, methionine sulfoxide, 3-nitrotyrosine, and 3-Cl-tyrosine), or protein carbonyls (PCO) (1, 4).

Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress

isoprene, ethane, pentane, acetone), and other typically nonvolatile substances such as isoprostanes, peroxynitrite, or cytokines, can be measured in breath condensate (5).

Breath analysis: potential for clinical diagnosis and exposure assessment

Lipid peroxidation generates a variety of relatively stable decomposition end products, mainly [alpha],[beta]-unsaturated reactive aldehydes, such as malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), and 2-propenal (acrolein) (21, 22), and isoprostanes (23, 24), which can then be measured in plasma and urine as an indirect index of oxidative stress.

Biomarkers of oxidative damage in human disease

It has been shown that rofecoxib can cause a marked increase in nonenzymatic generation of isoprostanes and reduce the oxygen radical antioxidant capacity (23).

Expression of COX-2 mRNA in peripheral blood monocytes from patients with acute myocardial infarction and its significance

Plasma FZ isoprostanes and coronary artery calcification: the CARDIA study.

The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA study

Isoprostanes are a complex family of compounds produced from arachidonic acid.

Plasma 8-isoprostane concentrations in patients with age-related cataracts

Perluxan works promptly in concert with numerous biochemical pathways responsible for inflammation with both enzymatic and non-enzymatic targets such as prostaglandin E2, cyclooxygenase 1+2, interlukein-1 and isoprostanes.

Nutrition's growing role in fighting inflammation: scientific understanding of how to address inflammation through dietary strategies may help to control many chronic diseases

Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry.

Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling

Oxidative stress-induced peroxidation of membrane lipids eventually generates a variety of mainly [alpha], [beta] unsaturated reactive aldehydes, such as malondialdehyde (MDA), 4-hydroxy-2nonenal (HNE), 2 propenal (acrolein) and isoprostanes as terminal products, which also cause tissue damage (45).

Pharmacology of free radicals and the impact of reactive oxygen species on the testis

Lipid peroxides are significantly raised, as are urinary isoprostanes.

Autism spectrum disorder: a review of the current understanding of pathophysiology and complementary therapies in children

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