isoprostanes

[‚ī·sō′prä‚stānz]

(biochemistry)

A class of natural products that are isomeric with prostaglandins but are formed in vivo by the nonenzymatic, free-radical oxygenation of arachidonic acid.

References in periodicals archive ?

2005), to our knowledge, the relationship between As exposure and isoprostanes has not been evaluated in human populations.

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study

Also, only supplemented subjects experienced a 7% drop in isoprostanes, a marker of how much oxidized fat is present and overall oxidative stress.

Arterial plaque rupture

Increased levels of isoprostanes (IsoPs) in cerebrospinal fluid, plasma and urine of subjects with MCI, suggested that increased oxidative stress occurs before the onset of symptomatic dementia (18,30).

The benefit of arm swing exercise on cognitive performance in older women with mild cognitive impairment

Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants.

Effects of Soil Sterilization on Growth of Angelica sinensis Plant and Soil Microbial Populations in a Continuous Mono-cropping Soil

As a result of lipid peroxidation increases in the levels of conjugated diens, isoprostanes, 4-HNE and malondialdehyde have been demonstrated.

Is 4-hydroxynonenal a predictive parameter for the development of joint erosion in patients with rheumatoid arthritis?

Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis.

An update on equine laminitis/Atualizacao sobre laminite equina

2]- 2010 [52] isoprostanes, hydroxyeicosatetraenoic acid products, 7B-and 27-hydroxycholesterol, 7- ketocholesterol, neuroprostanes, and urinary 8- hydroxy-2i deoxyguanosine) significantly higher in subjects with PD when compared to controls Keeney et al.

An integrated review of psychological stress in Parkinson's disease: biological mechanisms and symptom and health outcomes

Perluxan works promptly in concert with numerous biochemical pathways responsible for inflammation with both enzymatic and non-enzymatic targets such as prostaglandin E2, cyclooxygenase 1+2, interlukein-1 and isoprostanes.

Nutrition's growing role in fighting inflammation: scientific understanding of how to address inflammation through dietary strategies may help to control many chronic diseases

Some of the products of LP such as malondialdehyde (MDA), 4--hydroxynonenal (4-HNE), various 2alkenals and Isoprostanes are of toxicological interest [14].

Free radicals, antioxidants and disease

the majority of authors have noted an increase in TBARS following a variety of exercise protocols, whereas null findings appear much more common when measuring MDA or isoprostanes specifically suggesting that TBARS lack of specificity of the assay which might explain possible discrepancies of the results [14].

Oxidative stress status in elite athletes engaged in different sport disciplines

Oxidative stress-induced peroxidation of membrane lipids eventually generates a variety of mainly [alpha], [beta] unsaturated reactive aldehydes, such as malondialdehyde (MDA), 4-hydroxy-2nonenal (HNE), 2 propenal (acrolein) and isoprostanes as terminal products, which also cause tissue damage (45).

Pharmacology of free radicals and the impact of reactive oxygen species on the testis

Lipid peroxides are significantly raised, as are urinary isoprostanes.

Autism spectrum disorder: a review of the current understanding of pathophysiology and complementary therapies in children

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