isoprostanes

isoprostanes

[‚ī·sō′prä‚stānz]
(biochemistry)
A class of natural products that are isomeric with prostaglandins but are formed in vivo by the nonenzymatic, free-radical oxygenation of arachidonic acid.
References in periodicals archive ?
2005), to our knowledge, the relationship between As exposure and isoprostanes has not been evaluated in human populations.
Also, only supplemented subjects experienced a 7% drop in isoprostanes, a marker of how much oxidized fat is present and overall oxidative stress.
Increased levels of isoprostanes (IsoPs) in cerebrospinal fluid, plasma and urine of subjects with MCI, suggested that increased oxidative stress occurs before the onset of symptomatic dementia (18,30).
Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants.
As a result of lipid peroxidation increases in the levels of conjugated diens, isoprostanes, 4-HNE and malondialdehyde have been demonstrated.
Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis.
2]- 2010 [52] isoprostanes, hydroxyeicosatetraenoic acid products, 7B-and 27-hydroxycholesterol, 7- ketocholesterol, neuroprostanes, and urinary 8- hydroxy-2i deoxyguanosine) significantly higher in subjects with PD when compared to controls Keeney et al.
Perluxan works promptly in concert with numerous biochemical pathways responsible for inflammation with both enzymatic and non-enzymatic targets such as prostaglandin E2, cyclooxygenase 1+2, interlukein-1 and isoprostanes.
Some of the products of LP such as malondialdehyde (MDA), 4--hydroxynonenal (4-HNE), various 2alkenals and Isoprostanes are of toxicological interest [14].
the majority of authors have noted an increase in TBARS following a variety of exercise protocols, whereas null findings appear much more common when measuring MDA or isoprostanes specifically suggesting that TBARS lack of specificity of the assay which might explain possible discrepancies of the results [14].
Oxidative stress-induced peroxidation of membrane lipids eventually generates a variety of mainly [alpha], [beta] unsaturated reactive aldehydes, such as malondialdehyde (MDA), 4-hydroxy-2nonenal (HNE), 2 propenal (acrolein) and isoprostanes as terminal products, which also cause tissue damage (45).