kernicterus


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Related to kernicterus: hyperbilirubinemia

kernicterus

[kər′nik·tə·rəs]
(pathology)
Deposition of bilirubin in the gray matter of the brain and spinal cord, especially the basal ganglia, accompanied by nerve cell degeneration.
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The top three most common causes of CP in this study were birth asphyxia, CNS infections and kernicterus. This finding is in agreement with previous studies in Nigeria.
Definition of the clinical spectrum of kernicterus and bilirubin induced neurologic dysfunction (BIND).
Mr Jones added that the case was one of a number of claims from across the country being handled by his firm for similar mistakes resulting in kernicterus affecting other children.
Mollison and Cutbush noticed a close relationship between peak serum bilirubin concentration and development of kernicterus. [21] In mature infants, kernicterus seldom developed when serum bilirubin concentrations were less than 18 mg/dL.
There is currently a gap in point of care testing devices for G6PD, a deficiency that leads to hyperbilirubinemia and approximately 21% of kernicterus cases.
Trendsin hospitalizations for neonatal jaundice and kernicterus in the United States, 1988-2005.
The association between hyperbilirubinemia and encephalopathy was first described in 1847 by Hervieux; the term kernicterus was first used by Schmorl in 1903 to describe yellow staining of the basal ganglia [1].
[12] on socioclinical issues in CP in Sagamu, Nigeria, revealed that, of 92 patients attending the pediatric neurology clinic at Olabisi, Onabanjo University Teaching Hospital, Sagamu, Nigeria, between the periods of 2000 and 2006, birth asphyxia was associated with 57.6% cases, being the leading cause, kernicterus, 36.9%, and central nervous system infection, 21.7%.
PARENTS OF INFANTS AND CHILDREN WITH KERNICTERUS (PICK)
Settlements, which depend on both adverse outcomes and their causality, such as the death of an adult from a missed critical cardiac biomarker result in the clinical laboratory or at the point of care, or the lifelong disastrous mental impairment of an infant from kernicterus following an overlooked elevated bilirubin level not treated promptly with phototherapy, can be in the range of millions of dollars.
In the final stage of pregnancy, use of the sulfamethoxazole/trimethoprim combination should be avoided due to the risk of neonatal kernicterus. As current treatment options, use of intravitreal klindamycin (1.0 mg/0.1 ml) and dexamethasone (400 [micro]g/0.1 ml) injections to avoid systemic toxicity has been reported.
Resulta particularmente interesante el conocer sobre G6PD especialmente por la presencia de factores de riesgo que con mayor o menor intensidad participan en el incremento de la frecuencia de trastornos congenitos en muchos paises del mundo, factores, entre los que destacan problemas en la salud materna, elevada proporcion de madres mayores y de uniones consanguineas, que ubican a la deficiencia de G6PD dentro de los cinco defectos congenitos mas frecuentes a nivel mundial de lo mas de 7.000 defectos de origen genetico o parcialmente genetico, y considerado en combinacion con la enfermedad hemolitica Rhesus como importante factor de riesgo para muerte neonatal por kernicterus (2,3).