Reporting in an upcoming issue of the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, the investigators show that bits of liver cells, which contain nicotine-metabolizing enzymes, can convert nicotine into keto acid
without going through a cotinine stage.
The choice of derivatizing reagent which should convert polar keto acids
to nonpolar compounds for reproducible elution separation and determination from reversed phase HPLC.
Rexim's 17,000m2 Ham site mainly produces high quality pharmaceutical grades of amino acids, their salts and derivatives, as well as peptides and keto acids
Accumulation of these 3 amino acids and their corresponding keto acids
leads to encephalopathy and progressive neurodegeneration in untreated infants.
Increased amounts of keto acids
, including phenylpyruvate, were detected during analysis of the urine.
The amination of keto acids
is assumed to be more important then the elimination of ammonia (Fairbairn, 1957).
The [beta]-ketoglutarate (KGOR), aromatic aryl acids (IOR), the keto acids
derived from the branched chain amino acids (VOR), and pyruvate (POR) are oxidized to the corresponding aryl- or acyl-CoA compounds, with concomitant release of C[O.sub.2].