antifungal agent

(redirected from ketoconazole)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

antifungal agent

[‚an·tē′fəŋ·gəl ‚ā·jənt]
(materials)
A chemical compound that either destroys or inhibits the growth of fungi.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Yeast colony inoculum was evenly cultured onto SDA media and after that ketoconazole, fluconazole, and miconazole disc placed on the media surface.
Conclusion: Combination of 2% ketoconazole solution wash plus topical 1% clotrimazole was found more effective in treatment of patients with Pityriasis versicolor as compared totopical 1% clotrimazole alone.
Keywords: Dandruff, Myrtus communis L., Ketoconazole, Seborrheic dermatitis, Traditional Persian medicine.
Ketoconazole is an imidazole derivative, meaning that there are 2 nitrogen atoms in the azole ring.
Drug susceptibility was assessed using FUNGITEST[R] (Sanofi Diagnostics Pasteur) for the analysis of fungal growth in the presence of six drugs, such as 5-fluorocytosine, amphotericin B, miconazole, ketoconazole, itraconazole and fluconazole used at two concentrations, in modified RPMI 1640 medium, in the presence of a redox indicator.
One of the studies cited by the FDA in its regulatory decision reported that ketoconazole was associated with the highest relative risk (RR = 228; 95% CI: 33.9-933.0) when compared to nonusers, followed by itraconazole (RR = 17.7; 95% CI: 2.6-72.6) and terbinafine (RR = 4.2; 95% CI: 0.2-24.9) [21].
This finding is in correlation with other studies, suggesting that the synthesizing of a triazole derivative with coumarin moiety, in presence of the nitro group at the para position of the benzene ring, makes the compound's antifungal activity comparable to that of ketoconazole (12.5 [micro]g [mL.sup.-1]) [33].
This second observation confirms the efficacy of ketoconazole (10 mg/kg/day) for eight weeks even in case of severe basidiobolomycosis infection with alteration of general condition.
Oral Ketoconazole @5 mg/kg, parenterally antibiotic with Ciprofloxacin (a) @ 10mg/kg b.wt.
The advisory, issued on May 19, points out that oral ketoconazole (Nizoral) is no longer approved for treating nail or skin fungal infections.
In conclusion, we could not get any benefit from bicalutamide treatment in our patients, whereas ketoconazole treatment is promising in short term.
Antifungal sensitivity was tested against fluconazole, voriconazole, ketoconazole and amphotericin B and the results can be observed in Table 1.