Herds are usually monitored for hyperketonemia by regular assessment of the percentage of fresh cows having ketone body
concentrations above a defined threshold value.
However, concurrent butyrate supplementation in the form of sodium, calcium, or potassium butyrate (or its esters) will prompt the body to induce endogenous ketone synthesis; serve as a ligand to stimulate receptors that the ketone or ketone body
will also act on; contribute to the improvement of insulin and general metabolic health; support inflammatory and general immune system health; support neurological health; support gastrointestinal health and integrity; and serve as an energy substrate for ATP generation directly--all in parallel with the benefits that concurrent supplementation of the sister ketone body
(BHB) will provide.
Eaton, "Dose response to insulin in man: differential effects on glucose and ketone body
regulation," The Journal of Clinical Endocrinology & Metabolism, vol.
In contrast, neonates who received formula supplementation mounted a less favorable ketone body
response, and those who were exclusively formula-fed had the least favorable response, regardless of body size.
Significance of blood ketone body
ratio as an indicator of hepatic cellular energy status in jaundiced rabbits.
The maximum amount of daily ketone body
production in adults is 150 g .
This idea however does gain some support from recent studies which demonstrate that ketone body
supplementation can improve cognitive function in mild cognitive impairment (MCI) and AD ).
Urine ketone body
concentrations are usually two to four times higher than blood concentrations, whereas, milk ketone body
concentrations are usually 40 to 50 per cent of blood concentrations.
[beta]-Hydroxybutyrate (BHB) is a ketone body
synthesized in vivo and used as an energy substrate during nutritional starvation such as suckling, fasting and hibernation (Kabine et al., 2003; Haces et al., 2008).
Some investigators have indicated that PG supplementation can reduce serum NEFA and ketone body
concentrations (Christensen et al., 1997; Miyoshi et al., 2001; Pickett et al., 2003), and has been reported to increase milk production (Formigoni et al., 1996; Lucci et al., 1998).