The action of ethanol on the hypothalamuspituitary-adrenal axis is shown through his functional activation [6; 9; 11], phenomenon that induces the hypersecretion of oxys ketosteroids
Pincus, "Circadian rhythm in the excretion of urinary ketosteroids
by young men," Journal of Clinical Endocrinology & Metabolism, vol.
Endocrine control of female reproduction is governed by a variety of hormonal and neuronal factors that involve neuropeptide hormones, such as gonad-stimulating hormone (GSH) and vitellogenesis-inhibiting hormone (VIH); terpenoids, such as methyl farnesoate, a stimulator of vitellogenesis; ketosteroids
, such as ecdysteroids; and finally sex steroids such as estradiol and progesterone (Huberman, 2000; Zapata et al., 2003).
In addition to its role in the biosynthesis of 3[beta]-Adiol from 5a-DHT, this nicotinamide adenine dinucleotide (NAD (+))-dependent enzyme catalyzes the conversion of pregnenolone, 17[alpha]-hydroxypregnenolone, DHEA, and androstenediol into their respective ketosteroids
: progesterone, 17a-hydroxyprogesterone, androstenedione, and testosterone (Figure 1).