kinesin


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kinesin

[kī′nēs·ən]
(cell and molecular biology)
An enzyme that hydrolyzes adenosine triphosphate to provide energy to power anterograde [from (-) to (+)] movement along microtubules.
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Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.
Saenz-Morales et al., "miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target," PLoS One, vol.
These include hypoxia-inducible factor 2 alpha (HIF2A), fumarate hydratase (FH), prolyl hydroxylase types 1 and 2 (PHD1 and PHD2), Harvey rat sarcoma viral oncogene homolog (HRAS), kinesin family member 1B (KIF1B), and X-linked alpha thalassemia mental retardation (ATRX) genes [16-20].
Similar to TDP-43, FUS is involved in the transport of RNA granules in dendrites [111] using conventional kinesin and dynein as motors [101] and can move into spines in response to glutamate activation [111] through an actin-based motor protein myosin-Va [112].
miRNAs Target Gene description PSMB5 Proteasome (prosome, macropain) subunit, beta type 5 KIF3B Kinesin family member 3B hsa-miR-127-3p ITGA6 Integrin, alpha 6 BCAS3 Breast carcinoma-amplified sequence 3 MTSS1L Metastasis suppressor 1-like SP3 Sp3 transcription factor MYCBP2 MYC-binding protein 2, E3 ubiquitin protein ligase hsa-miR-493-5p TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG box) UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 HIPK1 Homeodomain-interacting protein kinase 1 RAB10 RAB10, member RAS oncogene family UBE2D2 Ubiquitin-conjugating enzyme E2D 2 hsa-miR-409-3p KANSL1 KAT8 regulatory NSL complex subunit 1 MTF2 Metal response element binding transcription factor 2 ELF2 E74-like factor 2 (ETS domain transcription factor)
Kinesin receptors are linker-cargo proteins essential for microtubule-dependent vesicle trafficking [39], and therefore, the target(s) of TPEN might interact indirectly with granules via kinesin.
Their complicated interactions as well as their relations with the surrounding structures and associated motor proteins (e.g., Dynein or Kinesin for microtubules or Myosin II for F-actin) are crucial for proper axonal development, they also are heterogeneously dispersed along the axon domain" (Wickstead and Gull, 2011, p 515).
Microtubule patterns of geometry can be observed using enhanced dark-field light microscopy in conjunction with hyperspectral imaging to observe nanomaterials such as kinesin in cells.
of selected The reduced features subsets Best Accuracy features (%) 2 {1613, 1165; 1427, 1479} 85 3 {156, 1606, 1601} 95 4 {1434,1775, 2214,1920} 100 Most important 1434- kinesin family member 3C features subset 1775- guanosine monophosphate reductase 2214- FYN oncogene related to SRC, FGR, YES 1920- lamin B2 Figure 2: The accuracy versus number of features for breast cancer dataset.
Importantly, kinesin motor-mediated axonal transport is impaired in AD, where p-tau is reported to impair kinesin-dependent axonal cargo trafficking by blocking transport of the adaptor-molecule c-Jun N-terminal kinase interacting protein 1 from the cell body to axons.[50]
A novel kinesin 13 protein regulating rice seed length.
This self-propelling fluid, which the authors of the study say holds promise for the creation of an entirely new class of fluids that can flow without any mechanical effort, was developed using filaments called microtubules and tiny molecular motors called kinesin.