The primary endpoint of the essential tremor study is to compare the effect of one week of SAGE-217 on overall kinetic tremor
symptoms, disclosed the company.
Patient A was under ART with tenofovir (TDF), lamivudine (3TC), atazanavir (ATV) and ritonavir (r), had no cognitive complaints and a last reported Mini Mental State Exam (MMSE) of 29/30; he had mild bilateral bradykinesia in upper extremities and postural, rest and kinetic tremor
in the right arm that did not interfere with activities of daily living and therefore was not on any antiparkinsonian drug.
All of these patients had bilateral postural hand tremor; in advanced cases, additional kinetic tremor
No subject had a kinetic tremor
in either of the two groups.
Hallmarks of encephalitis, in which the infection involves brain tissue, are a change in mental status and a variety of movement disorders, including postural or kinetic tremor
The kinetic tremor
is the tremor which occurs during movement.