kinetochore


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Related to kinetochore: centrosome

kinetochore

[kə′ned·ə‚kȯr]
(cell and molecular biology)
Within the centromere, the granule upon which the spindle fibers attach.
References in periodicals archive ?
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.
The ultrastructure of the nonlocalized kinetochores of Luzula and Cyperus.
More sophisticated and less destructive methods were slowly developed and in 1942, Carlson studied embryonic neuroblasts of Chortophaga (Carlson 1942), perforating living cells with a microneedle to manipulate the spindle and associated chromosomes; he determined that the latter were mechanically attached to the spindle, which was a semisolid longitudinal structure, through their kinetochores from prophase through late anaphase.
There are a number of mechanisms that can give rise to numerical CIN, including centrosome amplification, spindle assembly checkpoint bypass, malfunctions in sister chromatid cohesion and abnormalities in kinetochore structure or function (42).
Holocentric chromosomes of arachnids: presence of kinetochore plates during meiotic divisions.
Comparing SUMOylation in humans and rodents may provide important insights into centromere formation and kinetochore assembly.
4B, C), including the monitoring of microtubule numbers in kinetochore fibers in maloriented bivalents (LaFountain and Oldenbourg.
Kinetochores are crucial for accurate chromosome segregation because they link chromosomes to spindle microtubules.
As the kinetochore fibers shorten in anaphase, the spindle becomes more rod-shaped (Fig.
In this model, centric fusion is the result of recombination between centromeric satellite DNA sequences shared by the different autosomes: if the enzyme machinery failed to separate a pair of replicating telomeres, then two chromosomes could be joined and one of the two kinetochore organizer sequences could be inactivated (Redi & Capanna 1990).