kringle domain


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kringle domain

[′kriŋ·gəl dō‚mān]
(biochemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The binding is lysine dependent, suggesting Kringle domain involvement [38].
uPA consists of three structural regions, a C-terminal serine protease domain (159-411), a Kringle domain (50-132), and a growth factor domain (GFD; 10-43) [75].
The extracellular part of Ror proteins contains an immunoglobulin domain, a cysteine rich domain, also called a frizzled domain and a kringle domain (3-7).
Kringle domain 5 is known for its antiendothelial cell growth ability.
One group of antiangiogenic factors, plasminogen kringle domains, generated by the proteolytic cleavage of the blood coagulation-related proteins, can be considered a novel target in the pathogenesis of GN.
skillfully hides her kringle domains as she links up and embeds
Like plasminogen, apo(a) is composed of two kringle domains and a serine protease domain.
NK4 is an elastase-generated fragment of hepatocyte growth factor (HGF) containing four kringle domains, initially discovered as a competitive antagonist of HGF.
"The Biolex team has successfully produced a wide range of human proteins and monoclonal antibodies including Plasminogen, a protein that contains multiple kringle domains similar to those in NK4," said Kunio Iwatani, CEO of Kringle Pharma.
tPA is composed of five distinct structural domains; a finger region, an epidermal growth factor-like sub-domain, two kringle domains, and finally, the catalytic domain.
Structural relationship of an apolipoprotein (a) phenotype (570 kDa) to plasminogen: homologous kringle domains are linked by carbohydrate-rich regions.
apo(a) is highly glycosylated (3, 4), with numerous Oglycosidic linkages in the regions between the kringle domains (5).