kynurenic acid


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kynurenic acid

[¦kin·yə¦ren·ik ′as·əd]
(biochemistry)
C10H7O3N A product of tryptophan metabolism found in the urine of mammals.
References in periodicals archive ?
Disruption of the tryptophan-kynurenine pathway may result in elevations of xanthurenic acid (XANA) and kynurenic acid (KYNA), which may cause a decrease in liver nicotinamide adenine dinucleotide (NA[D.sup.+]) synthesis.
Five potential screened biomarkers (creatine, L-carnitine, tryptophan, tyrosine, and kynurenic acid) were further confirmed by the retention time comparison with the standard.
Kynurenic acid, 3-HAA, and QA, primarily as a consequence of the polar nature and the seeming absence of effective transition procedures, are not the same as a range of different kynurenine pathway metabolites because they cannot effectively cross the blood-brain barrier [18].
The induction of IDO and TDO leads to increased concentration of kynurenine pathway metabolites, mostly kynurenic acid and quinolinic acid.
One of the most studied metabolites of the kynurenine pathway is kynurenic acid (KYNA), which is so far the only known endogenous NMDA receptor antagonist.
However, we showed previously that, in Goldblatt 2-kidneys, one-clip (2K1C) model, microinjection of kynurenic acid, a broad spectrum EAA receptor antagonist, into the RVLM, reduced BP to the same extent as autonomic blockade [5].
A synthetic analogue of kynurenic acid, a naturally occurring neural regulatory compound, 7-C1KYNA is one of the most potent and selective blockers of the regulatory GlyB-site of the NMDA receptor.
Folate (5-methyltetrahydrofolate), riboflavin, flavin mononucleotide (FMN), [7] FAD, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxic acid, free choline, betaine, dimethylglycine, creatinine, methionine sulfoxide, arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, xanthurenic acid, 3-hydroxyanthranilic acid, and formiminoglutamic acid, were determined by liquid chromatography--tandem mass spectrometry (14-17), and methylmalonic acid, total homocysteine, total cysteine, methionine, serine, glycine, cystathionine, and sarcosine by gas chromatography-tandem mass spectrometry (15, 18).