kynurenic acid


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kynurenic acid

[¦kin·yə¦ren·ik ′as·əd]
(biochemistry)
C10H7O3N A product of tryptophan metabolism found in the urine of mammals.
References in periodicals archive ?
The induction of IDO and TDO leads to increased concentration of kynurenine pathway metabolites, mostly kynurenic acid and quinolinic acid.
0 mM) for 24 h Kynurenic acid (KYNA), a tryptophan metabolite known to own mitochondrial protection effect and attenuate [MPP.
As reported in the January 15, 2015 issue of Cell, the researchers found that when worms were given access to food after they d been denied it, they would overeat for a while before resuming their typical feeding pattern, a change in behavior triggered by falling levels of kynurenic acid.
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naive and medication-free schizophrenic patients.
When researchers decreased the levels of kynurenic acid in the brains of mice, their cognition was shown to improve markedly, according to the study.
Furthermore, we also confirmed the functional importance of altered expressions of these receptors in the recovery process in the PIT model, using kynurenic acid as an antagonist for glycine/glutamate receptors (10).
The lead author's laboratory studied the effects of a broad-spectrum glutamate receptor antagonist, kynurenic acid (KYNA), on glutamate- and noise-induced trauma in guinea pigs.
7-CI-KYNA is a synthetic analogue of kynurenic acid, which is a naturally occurring neural regulatory compound and one of the most potent and selective blockers of the regulatory GlyB-site of the NMDA receptor.
Washington, November 19 (ANI): A research team in the United States says that the inability to solve problems among patients with schizophrenia may be due to elevated levels of a specific compound, called kynurenic acid, in their brains.
Furthermore, a wide range of analytical services for the measurement of molecules recovered by microdialysis and other methods from brain and other organs or preparations will be offered; these include adenosine, nitric oxide, kynurenic acid, reactive oxygen species, glucose, lactate, as well as cyclic-AMP and -GMP, neuropeptides, cytokines, hormones and growth factors.
Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status.