kynurenine


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kynurenine

[‚kin·yə′re‚nēn]
(biochemistry)
C10H12O3N2 An intermediate product of tryptophan metabolism occurring in the urine of mammals.
References in periodicals archive ?
The company's preclinical programmes attack components of the IDO and TDO pathways by targeting their resultant immunosuppressive metabolite kynurenine as well as a downstream receptor.
In addition, the study found that the amount of lactobacillus in the gut affects the level of a metabolite in the blood called kynurenine which has been shown to drive depression.
Indolamine 2,3-dioxygenase (IDO), first and rate-limiting enzyme of kynurenine (Kyn) pathway, is a tryptophan (Trp) degrading enzyme having immunoinflammatory effects.
Amino acid tryptophan will break into stable metabolite called kynurenine when the IDO level increases.
Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme for tryptophan metabolism through the kynurenine pathway, exhibits an immunosuppressive effect and induces immune tolerance in tumor cells.
Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGF[beta], and IDO1.
When IDO is active, it shifts tryptophan down the kynurenine pathway rather than the serotonin pathway.
Abstract: Tryptophan 2,3-dioxygenase (TDO) exist only in liver while indoleamine 2, 3-dioxygenase (IDO) exists ubiquitously in the body, these are the most rate-limiting enzymes of kynurenine pathway (KP).
Development of a new piggyBac vector for generating transgenic silkworms using the kynurenine 3-mono oxygenase gene.
IDO1 and TDO overexpression leads to tryptophan depletion and high tumour levels of the breakdown product, kynurenine.
Vecsei, "Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders," Journal of the Neurological Sciences, vol.