l-dopa


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Related to l-dopa: levodopa, dopamine, Mucuna pruriens

l-dopa

(ĕl-dō`pə), drug used to alleviate some of the symptoms of Parkinson's diseaseParkinson's disease
or Parkinsonism,
degenerative brain disorder first described by the English surgeon James Parkinson in 1817. When there is no known cause, the disease usually appears after age 40 and is referred to as Parkinson's disease; a number of genes have
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, particularly trembling, rigidity, and slow movements; the drug is also called levodopa. Parkinson's disease results when the concentration of dopamine in the brain is depleted (see catecholaminecatecholamine
, any of several compounds occurring naturally in the body that serve as hormones or as neurotransmitters in the sympathetic nervous system. The catecholamines include such compounds as epinephrine, or adrenaline, norepinephrine, and dopamine.
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). Medical administration of dopamine itself is ineffective since that chemical apparently does not enter the brain from the blood. A metabolic precursor of dopamine, l-dopa does enter the brain via the bloodstream and is probably converted into dopamine there. Because there are many brain disorders with similar symptoms, many patients do not show any improvement when treated with the drug. Virtually all patients on l-dopa experience side effects including nausea, loss of appetite, cardiac irregularities, and psychological changes.
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L-dopa

[¦el ′dō·pə]
(pharmacology)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
L-dopa delivers dopamine to the brain to relieve symptoms.
Louis, MO), 1 in 1x PBS and another in AcOH/CTAB, and 2 1 mg [mL.sup.-1] L-DOPA solutions (Tocris Bioscience, Bristol, United Kingdom), also in 1x PBS and AcOH/CTAB.
Results: Personality disturbances and dysexecutive functioning (dysexecutive symptoms, inhibition, social regulation) were significantly reduced post L-dopa treatment.
Conclusion: L-Dopa is an effective treatment for cortical dysfunctions, health related quality of life and fatigue in I-PD.
Experimental Groups and Treatment: All the animals received chronic intermittent intraperitoneal (ip) injections of either L-dopa or saline twice daily (at 9 a.m.
The concentration of L-dopa (substrate) was set 1.25 mM, and 120 [micro]L in a sodium phosphate buffer (pH 6.8) was used for testing in a 96-well plate.
Since sensitivity to catecholamines in the heart is increased in patients using L-Dopa, these agents, especially halothane, should be avoided in such patients.
A total number of 42 rats were used in this experiment, 21 days after the surgery, animals were randomly divided into three groups ( n = 14 each group): (a) sham group (sham-operated, treated with saline); (b) 6-OHDA group (6-OHDA-lesioned, also treated with saline); and (c) L-DOPA group (6-OHDA-lesioned, treated with L-DOPA).
Mushroom (Agaricus bisporus) tyrosinase (3393 units/mg) and L-3,4-dihydroxyphenylalanine (L-DOPA) were purchased from Sigma-Aldrich and maintained at temperatures below -10 [degrees]C.
Rolon M y col (2007) refieren que frente a cuadros extrapiramidales progresivos en la infancia, es oportuno realizar, antes de emprender estudios mas complejos, la prueba terapeutica con L-Dopa, ya que si mejora el cuadro confirma la enfermedad.
Furthermore, the animal model they used were all different; seven studies assessed the effect on healthy naive human and animals [26,29-31, 34], three used immobilization stress to decrease [42] or increase [23, 35] the activity of LC before acupuncture treatment, one used L-dopa induced hyperactivated bladder model [32],and finally one study used CFA-induced inflammatory pain model [27].
Then add 40 [micro]L of tyrosinase solutions (0.693 (2.5 U/mL), 1.386 (5 U/mL), 2.772 (10 U/mL), 5.544 (20 U/mL), 6.93 (25 U/mL), and 11.088 (40 U/mL) [micro]g/mL, resp.) in a sodium phosphate buffer at pH 6.8 (PBS) and 120 [micro]L of the 0.625 mM of L-dopa solution (dissolved in PBS).