The expression of AQP-5 in labial glands from Sjogren's syndrome patients has been investigated.
Subsequently biopsy specimens obtained from labial glands were tested for AQP-5 expression and immunoreactivity using an AQP-5 ELISA kit and immunohistochemistry.
The expression of AQP-5 in labial glands increased by about 35% after D.
We analyzed factors such as age, smoking, severity of dryness according to the EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI) , fatigue assessed using the visual analogue scale (VAS) (0-10cm) , intensity of inflammation in labial glands (LSB)  assessed by focus score (FS), organ pathology assessed using the EULAR Sjogren's syndrome disease activity index (ESSDAI) , laboratory tests such as anti-nuclear antibodies (ANA), extractable nuclear antigens (ENA), rheumatoid factor (RF), inflammatory parameters (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)), full blood count, and protein electrophoresis.
No relationship between severity of fatigue reported by patients and laboratory test results or lymphocytic infiltration in labial glands was found.