The beta lactams
, cephalosporins, glycopeptides, fluoroquinolones, and carbapenems all have failed to eradicate infection with Gram-positive and Gram-negative superbugs (e.
Steroidal-4-en-3-ones such as 4-cholesten-3-one were treated with ozone to obtain a keto acid, 3,5-seco-4-norcholestan-5-on-3-oic acid (I), subsequently treated with amines to obtain enamine lactams
which were discovered to react with Grignard reagents at elevated temperatures to yield novel unsaturated 3-alkyl derivativatives.
Named Hanhwa Lactam
, the joint venture will have a total production capacity of 140,000 metric tons that will be executed in stages beginning with an initial annual output of 70,000 metric tons.
It consists of ceftazidime, a third-generation, cephalosporin, that is an established and respected treatment for serious Gram-negative bacterial infections, and avibactam, a non-[eth] lactam
PPG Industries has received a patent for a compound that is comprised of the reaction product of a highly branched polymer having terminal amine functional groups and a lactam
, wherein the highly branched polymer is the step-growth polymerization reaction product of a polyfunctional first monomer having a first functional group and a polyfunctional second monomer having a second functional group wherein the first and second functional groups will react with each other but not themselves, wherein formation of the highly branched polymer is free of self-condensation of the polyfunctional first monomer, and free of self-condensation of the polyfunctional second monomer.
INDEX TERMS: Pseudomonas aeruginosa, anti-Pseudomonas antibiotics, Beta Lactams
Positive samples for Beta Lactams
were found in multiple rooms as well as inside the ductwork prior to decontamination.
While beta lactams
are preferred for ABS, newer macrolides and fluoroquinolones are routinely chosen to treat AECB and CAP.