lactate


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lactate

an ester or salt of lactic acid

Lactate

A salt or ester of lactic acid (CH3CHOHCOOH). In lactates, the acidic hydrogen of the carboxyl group has been replaced by a metal or an organic radical. Lactates are optically active, with a chiral center at carbon 2. Commercial fermentation produces either the dextrorotatory (R) or the levorotatory (S) form, depending on the organism involved. See Optical activity

The R form of lactate occurs in blood and muscle as a product of glycolysis. Lack of sufficient oxygen during strenuous exercise causes enzymatic (lactate dehydrogenase) reduction of pyruvic acid to lactate, which causes tiredness, sore muscles, and even muscle cramps. During renewed oxygen supply (rest) the lactate is reoxidized to pyruvic acid and the fragments enter the Krebs (citric acid) cycle. The plasma membranes of muscle and liver are permeable to pyruvates and lactates, permitting the blood to transport them to the liver (Cori cycle). Lactates also increase during fasting and in diabetics. See Biological oxidation, Carbohydrate metabolism, Citric acid cycle

Lactates are found in certain foods (sauerkraut), and may be used for flour conditioning and in food emulsification. Alkali-metal salts act as blood coagulants and are used in calcium therapy, while esters are used as plasticizers and as solvents for lacquers. See Ester, Salt (chemistry)

lactate

[′lak‚tāt]
(organic chemistry)
A salt or ester of lactic acid in which the acidic hydrogen of the carboxyl group has been replaced by a metal or an organic radical.
(physiology)
To secrete milk.
References in periodicals archive ?
Thus, the purpose of this study was to determine if HRV thresholds could identify the lactate thresholds' intensity during a maximal, incremental running test.
9] These measurements were made only once and the temperature gradient and the arterial lactate level of these children were determined at the time of admission.
They blocked the production of lactate genetically in mice and showed that this prevented hair follicle stem cell activation.
Essentially, replacing lactate with fermented spices offers consumers a product with no added chemical additives.
Similarly, lactate levels of 4 mmol/L or higher during adult cardiac surgery has been associated with higher morbidity and mortality5.
1]); (b) blood lactate [greater than or equal to]8 mmol[?
The mean lactate values at the first admission, during the first 24 h, at 48 h, and during the CCU stay were recorded.
At 45 min postmortem, samples were taken from the longissimus dorsi (LD) muscles at the 8th-9th thoracic vertebra [12] for estimation of pH, glycogen, lactate and mRNA extraction study.
The second misconception is that lactate is responsible for acidifying the blood, thereby causing fatigue.
Almost none of them measure chemical signals, such as lactate.
Compared with neuropathological, neurochemical and genetic detection methods, the lactate stress test (LST) is a reliable, relatively easy-to-perform in vivo tool to screen patients for mitochondrial dysfunction.