An example of this phenomenon is paraoxon, the active metabolite of the pesticide parathion, which is metabolized by enzymes with native lactonase
activity (Khersonsky and Tawfik 2005).
After overnight incubation, production of violacein by CVO26 confirmed that the degradation activity was AHL lactonase
PON2 does not have esterase activity but is a potent lactonase
 and plays a significant role in atherosclerosis .
The pathway can be considered in two phases: the irreversible oxidative phase comprising the reactions catalyzed by glucose 6-phosphate dehydrogenase, lactonase
and 6-phosphogluconate dehydrogenase; and the reversible, non-oxidative phase involving the rest of the pathway, then: Regulation of the pentose phosphate pathway: The flow of metabolites through the pathway is regulated at the glucose 6-phosphate dehydrogenase reaction and the 6-phosphogluconate dehydrogenase by the availability of NADP +.
Transgenic Amorphophallus konjac expressing synthesized acyl-homoserine lactonase
(aiiA) gene exhibit enhanced resistance to soft rot disease.
AHL degrading enzyme that widely studied are AHL lactonase
and AHL acylase.
From evolutionary stand point, PON2 appears to be the oldest member, followed by PON3 and PONI (3) PON2 has lactonase
family cleaves the lactone ring of AHLs releasing N-acyl homoserines, which are not recognized as a QS signal, some examples include AiiA from Bacillus sp.
The measurement of the lactonase
activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.
Rabbit serum paraoxonase-3 (PON3) is a high-density lippoprotein-associated lactonase
and protects lipoprotein against oxidation.
It permits the postulation of the catalytic mechanism of the esterase and lactonase
function of PONs.
Paraoxonase (PON1) is an HDL-associated esterase/ lactonase
, which derived its name from one of its most commonly used in vitro substrates, paraoxon.