lactonase

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lactonase

[′lak·tə‚nās]

(biochemistry)

The enzyme that catalyzes the hydrolysis of 6-phosphoglucono-Δ-lactone to 6-phosphogluconic acid in the pentose phosphate pathway.

References in periodicals archive ?

An example of this phenomenon is paraoxon, the active metabolite of the pesticide parathion, which is metabolized by enzymes with native lactonase activity (Khersonsky and Tawfik 2005).

Biological Cleavage of the C-P Bond in Perfluoroalkyl Phosphinic Acids in Male Sprague-Dawley Rats and the Formation of Persistent and Reactive Metabolites

After overnight incubation, production of violacein by CVO26 confirmed that the degradation activity was AHL lactonase.

Quorum sensing and biofilm inhibition by lactonase producing Bacillus amyloliquefaciens SBF1 strain isolated from date palm rhizosphere of Saudi Arabia

PON2 does not have esterase activity but is a potent lactonase [72] and plays a significant role in atherosclerosis [73].

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

The pathway can be considered in two phases: the irreversible oxidative phase comprising the reactions catalyzed by glucose 6-phosphate dehydrogenase, lactonase and 6-phosphogluconate dehydrogenase; and the reversible, non-oxidative phase involving the rest of the pathway, then: Regulation of the pentose phosphate pathway: The flow of metabolites through the pathway is regulated at the glucose 6-phosphate dehydrogenase reaction and the 6-phosphogluconate dehydrogenase by the availability of NADP +.

Salicinium: a powerful biological response modifier in cancer

Transgenic Amorphophallus konjac expressing synthesized acyl-homoserine lactonase (aiiA) gene exhibit enhanced resistance to soft rot disease.

Transformation of Soft Rot Resistant aiiA Gene into Chinese Cabbage (Brassica rapa ssp. pekinensis) by the Pollen-tube Pathway

AHL degrading enzyme that widely studied are AHL lactonase and AHL acylase.

Characterization of bacteria producing acyl homoserine lactone (AHL) lactonase from agricultural lands

From evolutionary stand point, PON2 appears to be the oldest member, followed by PON3 and PONI (3) PON2 has lactonase activity (4).

Association of human monocytic paraoxonse 2 (PON 2) and serum nitric oxide levels in preeclampsia patients

The lactonase family cleaves the lactone ring of AHLs releasing N-acyl homoserines, which are not recognized as a QS signal, some examples include AiiA from Bacillus sp.

Identificacion, clonacion y actividad lactonasa de la proteina recombinante de N-acil homoserina lactonasa (AiiA) de Bacillus thuringiensis cepa 147-115-16

The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.

Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in C[Cl.sub.4]-intoxicated rats/ Extrato envelhecido de alho incrementa a atividade de paraoxonase 1 e suprime o estresse oxidativo em ratos intoxicados com C[Cl.sub.4]

Rabbit serum paraoxonase-3 (PON3) is a high-density lippoprotein-associated lactonase and protects lipoprotein against oxidation.

Paraoxonase 1 activity in endocrine diseases/Endokrin hastaliklarda paraoksonaz 1 enzim aktivitesi

It permits the postulation of the catalytic mechanism of the esterase and lactonase function of PONs.

Paraoxonases: structure, gene polymorphism & role in coronary artery disease

Paraoxonase (PON1) is an HDL-associated esterase/ lactonase, which derived its name from one of its most commonly used in vitro substrates, paraoxon.