activity and lipoproteinphospholipase A2 as possible novel serum biomarkers for the differential diagnosis of autism spectrum disorders and Rett syndrome: results from a pilot study," Oxidative Medicine and Cellular Longevity, vol.
Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase
and protects low density lipoprotein against oxidation.
An example of this phenomenon is paraoxon, the active metabolite of the pesticide parathion, which is metabolized by enzymes with native lactonase
activity (Khersonsky and Tawfik 2005).
Pei and Lamas-Samanamud (2014) showed that the engineered phage strain T7 which produces metalloenzymes AiiA lactonase
have various actions against signaling molecules (acyl homoserine lactones) involved in bacterial quorum sensing and that these molecules are important for biofilm development (53).
PON1 is an esterase and lactonase
that confer resistance to experimental infection with T.
This enzyme elicits three distinct hydrolytic activities: (1) paraoxonase, towards toxic organophosphates such as paraoxon, the toxic oxon metabolite of parathion, an insecticide; (2) arylesterase, towards nonphosphorous aryl esters, such as phenyl acetate; and (3) lactonase
, towards lactones .
When calcein-AM entered into mitochondria, it was excised by lactonase
to produce fluorescent calcein with strong polarity and then captured by mitochondria.
The pathway can be considered in two phases: the irreversible oxidative phase comprising the reactions catalyzed by glucose 6-phosphate dehydrogenase, lactonase
and 6-phosphogluconate dehydrogenase; and the reversible, non-oxidative phase involving the rest of the pathway, then: Regulation of the pentose phosphate pathway: The flow of metabolites through the pathway is regulated at the glucose 6-phosphate dehydrogenase reaction and the 6-phosphogluconate dehydrogenase by the availability of NADP +.
Transgenic Amorphophallus konjac expressing synthesized acyl-homoserine lactonase
(aiiA) gene exhibit enhanced resistance to soft rot disease.
AHL degrading enzyme that widely studied are AHL lactonase
and AHL acylase.
From evolutionary stand point, PON2 appears to be the oldest member, followed by PON3 and PONI (3) PON2 has lactonase
thuringiensis collection and described the cloning, sequencing and the activity of recombinant protein of a N-acyl homoserine lactonase