Peripapillary microvascular improvement and
lamina cribrosa depth reduction after trabeculectomy in primary open-angle glaucoma.
* Infiltration posterior to
lamina cribrosa, but not involving the cut end of Optic Nerve (Both also had less than 8 mm Optic Nerve length)--Two patients
Matsumoto et al., "Clinical factors associated with
lamina cribrosa thickness in patients with glaucoma, as measured with swept source optical coherence tomography," PLoS One, vol.
Elastosis of the
lamina cribrosa in pseudoexfoliation syndrome with glaucoma.
Optic nerve at the level of the
lamina cribrosa in an eye filled with silicone oil shows numerous clear spaces.
An intriguing finding of several studies is that intracranial pressure (ICP) is lower in patients with POAG and NTG [10-12], and a growing body of evidence indicates that glaucoma is a condition that develops from a mismatch in pressures across the
lamina cribrosa. The optic nerve, a white matter tract of the central nervous system (CNS), is ensheathed in all three meningeal layers and surrounded by cerebrospinal fluid (CSF) in the subarachnoid space (SAS) with a pressure equivalent to ICP [13].
Elastosis of the
lamina cribrosa in glaucomatous optic neuropathy.
Weinreb et al., "Three-dimensional evaluation of the
lamina cribrosa using spectral-domain optical coherence tomography in glaucoma," Investigative Ophthalmology & Visual Science, vol.
It has been suggested that constriction of the
lamina cribrosa pores in glaucoma act to compress the exiting CRV, causing a reduction in blood outflow from the retina and subsequently raise the pressure within the vessel.
Addicks, "Regional differences in the structure of the
lamina cribrosa and their relation to glaucomatous optic nerve damage," JAMA Ophtalmology, vol.
High-risk features evaluated included the presence and extent of optic nerve (ON) invasion with respect to
lamina cribrosa, the status of the ON cut margin, the presence of vitreous seedings, and invasion of the sclera, anterior chamber, and choroid.
(3) Due to the absence of connective tissue between the optic nerve fibers in the
lamina cribrosa region and the absence of myelin sheathing around the nerve fibers, the optic nerve head is a relatively weak structure.
