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Caption: Figure 7: Quantitative comparison of the mRNA expression of renin-angiotensin system components and proinflammatory cytokines in the lamina terminalis (LT (a)) and paraventricular nucleus (PVN (b)) of rats receiving renal denervation (RD), intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe), or TNF-[alpha] inhibitor etanercept (ENT) after isoproterenol (ISO) administration (n = 6/group; ([section]) P < 0.05 versus Sham + saline; * P < 0.05 versus Sham + saline or RD + saline; (#) P < 0.05 versus Sham + ISO).
LT, the lamina terminalis; PVN, the paraventricular nucleus of hypothalamus; SNA, sympathetic nerve activity.
Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat
The main central osmoreceptors (OVLT and SFO) and MnPO that are located in the forebrain lamina terminalis [9, 32, 42, 44] target PVN primarily.
Thunhorst, "Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis," Clinical and Experimental Pharmacology and Physiology, vol.
Median preoptic nucleus mediates the cardiovascular recovery induced by hypertonic saline in hemorrhagic shock
Oldfield, "Intravenous angiotensin II induces Fos-immunoreactivity in circumventricular organs of the lamina terminalis," Brain Research, vol.
Collister, "Role of the organum vasculosum of the lamina terminalis for the chronic cardiovascular effects produced by endogenous and exogenous ANG II in conscious rats," American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol.
Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing Copper/Zinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis

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