However, whether Cardiac glycoside Lanatoside C can induce oxidative stress in liver cancer cells and induce cell death both in vitro and in vivo remains unknown.
Results: In this study, we found that Cardiac glycosides, particularly Lanatoside C from Digitalis ferruginea could significantly inhibit PTEN protein adequate Huh7 and PTEN deficient Mahlavu human liver cancer cell proliferation by the induction of apoptosis and G2/M arrest in the cells.
Conclusion: The results indicated that Lanatoside C could be contemplated in liver cancer therapeutics, particularly in PTEN deficient tumors.
This study investigates the antitumor activity of cardiac glycosides, particularly Lanatoside C, in liver cancer cells both in vitro and in vivo.
Initial and majority of in vitro experiments were done with pure Lanatoside C (D.
Then 2 [micro]M Lanatoside C (L2261, Sigma Aldrich) was applied to the cells.
Control group mice (5 mice) received only simple syrup and other subjects received 6 mg/kg Lanatoside C (8 mice) in simple syrup by gavage feeding (5 days/week).