lanosterol


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lanosterol

[lə′näs·tə‚rȯl]
(biochemistry)
C30H50O An unsaturated sterol occurring in wool fat and yeast.
References in periodicals archive ?
Eventually, the researchers discovered that MI-2 directly inhibits lanosterol synthase, an enzyme involved in cholesterol production.
Eyedrops containing lanosterol showed reduced severity of cataracts in animal research.
The underlying mechanisms are primarily linked to structural changes or upregulation of the azole target lanosterol 14 a-demethylase encoded by cyp51A (1).
"This gene encodes lanosterol synthase LSS for short," notes study author Prof.
A team of researchers from the University Hospital of Bonn found that changes in the lanosterol synthase (LSS) gene lead to impairment of an important enzyme that has a crucial function in cholesterol metabolism.
Imidazole groups are known to display antifungal characteristics by interrupting the mechanism by which lanosterol demethylase converts lanosterol to ergosterol, a key component in fungal membranes; fungi without ergosterol in their membrane cannot control the passage of ions and nutrients across the membrane and therefore cannot survive [22].
This causes inhibition when the azole occupies the binding site instead of lanosterol, which in most fungi is the normal substrate (11).
Antifungal activity of cysteine, its effect on C-21 oxygenated lanosterol derivatives and other lipids in Inonofus obliquus, in vitro.
Actua inhibiendo la lanosterol 14-[alfa] demetilasa, enzima necesaria para la sintesis de ergosterol, por lo que altera la membrana fungica y el crecimiento celular (38).
Do mesmo modo, o processo de formacao da molecula do colesterol envolve a sintese do lanosterol e a sintese do colesterol propriamente dito (GRIMINGER, 1986).