lanosterol


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lanosterol

[lə′näs·tə‚rȯl]
(biochemistry)
C30H50O An unsaturated sterol occurring in wool fat and yeast.
References in periodicals archive ?
Besides, twenty-eight metabolites, which included malate, ethanolamide, squalene, glycerol, myristic acid, oleic acid, lanosterol, heptadecanoic acid and capric acid, were higher in late stage OA in comparison to early stage (50).
Target proteins docked were DNA gyrase, topoisomerase-IV of the bacteria, lanosterol 14-alpha-demethylase of the fungi, cycloxygenase-2 (Cox-2) and epidermal growth factor receptor tyrosine kinase (EGFR.
Its fungistatic action is attributed to its inhibitory action on 14[alpha]-demethylase, which converts lanosterol to ergosterol and is required in fungal cell wall synthesis.
Itraconazole is highly keratophilic and lipophilic triazole which impairs fungal cell wall synthesis by inhibiting cytochrome P 450 dependent 14 alpha lanosterol demethylase enzyme and interferes with fungal ergosterol synthesis7.
This functional pharmacophore works by blocking the active site of the enzyme known as lanosterol 14 [alpha]--demethylase or cytochrome P450.
The dockings of these molecules in the active sites of lanosterol demethylase, dihydrofolate reductase and topoisomerase II indicate their strong interactions with these enzyme [23].
450] dependent 14-[alpha] demethylase (CYP51A1), which converts lanosterol into ergosterol.
Efinaconazole is an azole-class drug that interferes with ergosterol biosynthesis by blocking lanosterol demethylase.
Koch A, Kumar N, Weber L, Keller H, Imani J and K-H Kogel Host-induced Gene Silencing of cytochrome P450 lanosterol C14 -demethylase-encoding Genes Confers Strong Resistance to Fusarium species.
The plant contains glycoalkaloids, flavonoids, tropane, lanosterol, arginine, gramisterol, aspartic acid as vital constituents.
The primary mechanism of fluconazole's action occurs by the inhibition of the fungal enzyme lanosterol 14[alpha]-demethylase (CYP51), which is a cytochrome enzyme P-450, involved in the synthesis of the ergosterol, the most important sterol in the fungal cell membrane [36].