Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas
compared to surfactant proteins A and B.
epidermoid) carcinoma, adenocarcinoma, and large cell carcinoma
The distribution of non-small cell lung cancer by histological type was 52 squamous cell carcinomas; 29 adenocarcinomas, including one adenocarcinoma with neuroendocrine characteristics and two bronchoalveolar carcinomas; and 8 large cell carcinomas
The term large cell carcinoma
has been used in some published clinical trials, but this diagnosis requires a resection specimen and cannot be made in small biopsies or cytology specimens, so it is not clear how these tumors were distinguished from NSCLC-NOS neoplasms.
KIF5B-RET fusion was not seen in any of the squamous cell carcinomas, large cell carcinomas
, and small cell lung carcinomas.
The type of lung cancer leading to fatal infection (n = 20 cases) was squamous cell carcinoma in 9 cases, adenocarcinoma in 5 cases, small cell carcinoma in 4 cases, undifferentiated large cell carcinoma
in 1 case, and non-small cell carcinoma in 1 case.
In the 2004 WHO classification, some neuroendocrine tumors have categories to themselves (small cell carcinoma [SCLC], carcinoid tumors), whereas another is a variant of large cell carcinoma
(large cell neuroendocrine carcinoma [LCNEC]).
6 Cause of death Alive 88 40 38 Lung cancer 251 109 109 Other cause 105 35 55 Non-Small Cell Large Cell Carcinoma
NOS Carcinoma Other (n = 21) (n = 30) (n = 7) Age Median 61.
PARAMOUNT was conducted specifically in patients with advanced nonsquamous NSCLC because past studies have shown that advanced NSCLC patients with a nonsquamous histology (those with the subtypes of adenocarcinoma, large cell carcinoma
or "other" histologies) experienced improved efficacy over the relative comparator arm in the trial, when treated with an ALIMTA regimen.
38) The combined SCLC is defined as SCLC in which there is a component of non-small cell carcinoma, including adenocarcinoma, squamous cell carcinoma, large cell carcinoma
, or uncommonly, sarcomatoid carcinoma.
The most common tumor cell type was adenocarcinoma, followed by squamous cell carcinoma, large cell carcinoma
, and adenosquamous carcinoma.
Pulmonary large cell carcinoma
with rhabdoid phenotype.