Large cell carcinoma
of the lung: clinical oriented classification integrating immunohistochemistry and molecular biology.
These tumor markers were not useful in discriminating adenocarcinoma and large cell carcinoma
. We classified large cell carcinoma
as adenocarcinoma in the present study (Figure 1).
Patients with squamous cell carcinoma (SqCC) had higher HA levels compared to adenocarcinoma (AD) and large cell carcinoma
(LCC) (log10 scale; P<0.001, Kruskal-Wallis test).
Out of the total 1498 cases Squamous cell carcinoma was found to be the most prevailing with 388 cases (26.08%) followed by Small cell carcinoma (19.08%) Adenocarcinoma (18.48%) Non- small cell carcinoma (16.73%) Carcinoid carcinoma (11.56%) undifferentiated carcinoma (4.23%) and large cell carcinoma
(3.83%) as shown in Figure.1.
Out of 28 patients, 27 cases (96.42 %) were diagnosed to have Non-small cell lung carcinoma category (NSCLC) which was further classified into Adenocarcinoma 9 cases (29.63%), Squamous cell carcinoma 8 cases (33.34%), Large Cell Carcinoma
3 cases (11.11%), Metastatic Carcinoma 2 cases (7.4%) and 5 cases (18.52 %) were unclassified.
Pakistani men with a male to female ratio of 4.4 - 7.6:1.6,7 The disease shows a peak between the ages of 51 and 70 years.7,8 The common presenting symptoms include cough, shortness of breath, chest pain, haemoptysis, fever, weight loss and anorexia.6 Histologically, carcinoma of lung is classified mainly into squamous cell carcinoma, small cell carcinoma, adenocarcinoma, large cell carcinoma
and other less common types.9
Immunohistochemistry can reclassify solid pattern tumors as adenocarcinoma, large cell carcinoma
, and in some instances, demonstrate adenosquamous histology.
Recent improvements in chemotherapy and radiation therapy  have resulted in the latter being further classified into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma
In pleomorphic carcinoma, the sarcomatoid component includes spindle or giant cells, alone or variably admixed, whereas the epithelial component is composed of conventional nonsmall cell lung carcinomas (NSCLCs) featuring adenocarcinoma, squamous cell carcinoma, or undifferentiated large cell carcinoma
Malignant lesions diagnosed by FNAC were primary & secondary neoplasm of liver, adeno carcinoma of various organs, sarcoma, neuroendocrine carcinoma, non-hodgkin's lymphoma, anaplastic carcinoma, mixed germ cell tumor, small cell carcinoma, squamous cell carcinoma, large cell carcinoma
, acinic cell carcinoma, Ewing's sarcoma, adrenocortical tumor, renal cell carcinoma, seminoma and various surface epithelial carcinomas of ovary.
HPV HPV16 Non-small-cell lung cancer 100 16% (16/100) 6% (6/100) Adenocarcinoma 43 23.5% (10/43) 6.9% (3/43) Squamous cell carcinoma 39 15.4% (6/39) 5.1% (2/39) NSCLC not otherwise specified 10 10% (1/10) 10% (1/10) Large cell carcinoma
4 0 0 Neuroendocrine type 2 0 0 HPV18 Double infection Non-small-cell lung cancer 11% (11/100) 1% (1/100) Adenocarcinoma 16.3% (7/43) 2.3% (1/43) Squamous cell carcinoma 10.3% (4/39) 0 NSCLC not otherwise specified 0 0 Large cell carcinoma
0 0 Neuroendocrine type 0 0
Point mutation analysis in K-ras codon 12 by Point-EXACCT detected K-ras point mutations in 15% of squamous cell carcinomas, 35% of adenocarcinomas, and 38% of large cell carcinomas
. Furthermore, one patient with a large cell carcinoma
and one patient with an adenocarcinoma showed a similar double mutation.