Attoub et al., "The stomach is a source of leptin
," Nature, vol.
Human endometrial endothelial cell and human umbilical vein endothelial cell isolation and experimental treatment with leptin
. Frozen primary HEECs (n=2) and HUVECs (n=1) were derived from banked samples.
"My colleagues and I started looking for what causes leptin
resistance in the brain when we eat fatty foods.
Further experiments showed that if the animals were genetically engineered to be leptin
deficient, then the treatment with the specific monoclonal antibody did not reduce appetite and weight in obese mice, indicating that GIP in the brain acts through leptin
Scientists know leptin
, a hormone produced by fat cells, is important in the control of body weight both in humans and mice.
In the case of weight gain, the brain becomes desensitised to rising leptin
levels and we keep eating.
, Anatolian water buffaloes, Adipose tissue, Feed intake, Marker assisted selection.
Recently it has been hypothesized that leptin
plays an important role in the development of histopathologic features of AD in addition to many genetic and environmental factor.
The Asp100Asn variant lies in the functional domain of the leptin
protein and has not been reported in the 1000 Genomes database.
Alteration in JAK2/STAT3 is implicated in impaired post-receptor leptin
Results: Highest Kisspeptin and Leptin
levels were seen in normal weight group (374.80 +- 185.08ng/L; 12.78 +- 6.8 pg/ml) respectively, yet the highest number of clinical pregnancy was observed in overweight group (42%).A strong correlation of Kisspeptin with Leptin
(r=0.794, p=0.001) was observed in the overweight females.
The researchers found that the obese patients with type 2 diabetes showed a positive correlation between plasma leptin
levels and a parameter for deep sleep assessed by delta power during the first sleep cycle.