Leukopenia

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leukopenia

[‚lü·kō′pē·nē·ə]
(medicine)
A reduction in the leukocyte count to values below the normal limit. Also known as leukocytopenia.

Leukopenia

 

leukocytopenia, a decrease in the absolute number of leukocytes in the peripheral blood.

Leukopenia is usually caused by a redistribution of blood that occurs with certain physiological conditions, such as with increased tonus in the vagus nerve, with diminished function in the adrenal cortex and in the sympathetic nervous system, after a hot bath, and with starvation. Cases are known of familial, “constitutional” leukopenia. Leukopenia may develop after infection or repeated blood transfusion (autoimmune and isoimmune leukopenias) or after taking certain drugs (sulfanilamides, Amidopyrine). It may have diagnostic significance with influenza, kala-azar, typhoid fever, brucellosis, malaria, and certain other diseases. Severe leukopenia develops in the presence of fatty degeneration of the bone marrow, an aplasia that arises as an independent disease (aplastic anemia), or as a result of severe intoxication (benzene, some drugs) or ionizing radiation.

REFERENCES

Istamanova, T. S., and V. A. Almazov. Leikopenii i agranulotsitozy. Leningrad, 1961.

G. A. ALEKSEEV

References in periodicals archive ?
Jadhav UM et al in 2003 studied 264 patients in tropical endemic areas of India and reported incidence of leucopenia more in P.
Because immunosuppressive drugs can markedly suppress the immune system and blood counts, TPE might be considered as an alternative treatment modality where conventional immunosuppressive therapy is contraindicated due to concomitant infection and leucopenia (as in eight of our patients).
En estudios previos se han establecido factores de riesgo para mortalidad como: trombocitopenia menor a 50 000 con (OR 11,7; IC 5,4-25,1), leucopenia menor a 2 500 (OR 3.1; IC 1.4-6.9), dificultad respiratoria (OR 2.8; IC 2.8- 6.1), coinfeccion bacteriana (OR 2.7; IC 1,2 - 6,1) e hipoalbuminemia (OR: 7; IC 1-27) (8,19,20).
In a nutshell, leucopenia increases the risk of infection by lowering the immunogenic threshold to ubiquitous and opportunistic pathogens.
Studies are divided into those that use a standard course (1.5mg/Kg for five to six doses) [21-24] and those that use a short course (1.5g/Kg for three to five doses) [27, 28] showing the same benefits and less degree of leucopenia and thrombocytopenia.
El efecto adverso asociado al tratamiento que se presento con mayor frecuencia fue leucopenia en 25% de los casos.
His complete blood count revealed mild hypochromic microcytic anemia with leucopenia. His erythrocyte sedimentation rate and C-reactive protein were elevated.
Se detecto anemia en 25,36% de los indigenas (53/209); 33,01% presento leucocitosis (69/209), 28,23% leucopenia (59/209) y 4,64% eosinofilia (9/194).
Clinico-hematological features might include thrombocytopenia, anemia, leucopenia, splenomegaly, and/or hepatomegaly (1).