leucovorin


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leucovorin

[lü′käv·ə·rən]
(pharmacology)
Folinic acid used as a calcium salt to counteract the toxic effects of folic acid antagonists and for treatment of megaloblastic anemias.
References in periodicals archive ?
Correlation between serum concentration of methotrexate and leucovorin rescue
The dose of leucovorin depends upon many factors like the type of cancer or condition being treated, height, weight, general health or other health problems of the patient.
Other measures include monitoring of blood creatinine and MTX concentrations, as well as pharmacokinetically guided leucovorin rescue to restore intracellular folate concentrations.
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.
The wound began to heal, and hydration, bicarbonate, and calcium leucovorin were given orally.
Hochster et al (32) have reported preliminary data utilizing oxaliplatin with weekly bolus 5-FU and low-dose leucovorin every 3 of 4 weeks in an ongoing single arm study in newly diagnosed advanced colorectal cancer patients.
The United States FDA has approved Merrimack's (NASDAQ: MACK) ONIVYDE (irinotecan liposome injection) in combination with fluorouracil (5-FU) and leucovorin (LV) on October 22.
Biopharmaceutical company PharmaEngine reported on Thursday the receipt of the US FDA's approval for Merrimack's (NasdaqGM:MACK) ONIVYDE (irinotecan liposome injection) in combination with fluorouracil (5-FU) and leucovorin (LV) for treating metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
In the Cetuximab Combined with Irinotecan in First-Line Therapy for Metastatic Colorectal Cancer CRYSTAL) study [5-fluorouracil, leucovorin and irinotecan (FOLFIRI) [+ or -] cetuximab], the rate of liver resection was increased from 1.
When it was combined with FOLFIRI (5-fluorouracil, leucovorin, and irinotecan), cetuximab produced partial tumor regression or stable disease in 88% of patients with metastatic colorectal cancer, an objective response rate not achievable with FOLFIRI alone.
Neutropenic Enterocolitis in an Adult Patient With Colon Carcinoma After Receiving 5-Fluorouracil and Leucovorin.
Although drugs against the infection are already available, researchers have considered trimetrexate a less toxic or more effective alternative if used in conjunction with leucovorin.