Hence, MDR1 overexpression in leukaemic
cells is associated with lower CR rate and higher relapsed rate in acute leukaemia, especially in old age.27
Linn, "Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic
blasts," Cancer Immunology, Immunotherapy, vol.
A quantitative reverse transcriptase polymerase chain reaction method for the detection of leukaemic
cells with t(8;21) in peripheral blood.
Human K562 myelogenous leukaemia cells, THP-1 acute monocytic leukaemia cells, CCRF-CEM leukaemic
lymphoblast cells and CCRF-CEM/C1 CPT-resistant leukaemic
lymphoblast cells were obtained from the American Type Culture Collection (ATCC, UK).
The most common cause is acute lymphoblastic leukaemia, where the normal bone marrow is being replaced by leukaemic
Differences in the distribution of CD34 epitopes on normal haemopoietic progenitor cells and leukaemic
Dr Abuljadayel said: 'The entire blood system was created from these leukaemic
But not all babies born with the "leukaemic
gene" called TEL-AML 1 in their blood go on to develop the disease, suggesting it could be triggered by a second "event" after birth.
Pitfalls in the immunophenotyping of leukaemia and leukaemic
lymphomas: survey of 9 years of quality control in The Netherlands.
Now researchers from St Jude Children's Hospital, Memphis, Tennessee, have found that by identifying cancer cells left over after treatment using a technique capable of detecting one leukaemic
cell among 10,000 normal cells, the possibility of a relapse can be predicted.
The term acute historically referring to a rapid onset and promptly fatal outcome, now indicates the relatively undifferentiated nature of the leukaemic
Results: A higher proportion of human parvovirus B19-positive cases was found in leukaemic
patients (n=19; 47.5%) compared to 12 (20%) in the control group (p(less than)0.05).