To our knowledge, this is the first documented case wherein electrolyte abnormalities similar to those seen in tumor lysis syndrome had complicated the course of a leukemoid
reaction in an extremely premature neonate.
A recent report of using a commercially available antibody discussed establishing normal LAP levels for individual hematology laboratories (7) The current study expanded on the use of a commercial primary antibody for clinical use by exploring different gating strategies, verifying assay conditions, and testing on new cases of CML or leukemoid
reaction and fever after polyvalent polysaccharide pneumococcal vaccination.
Conversely false negatives showing normal or high B12 levels despite coexistent cobalamin deficiency are in cases of recent cobalamin injections ,abnormalities of transcobalamin transport, metabolism or increased levels of transcobalamin, circulating antitranscobalamin antibody, leukaemia\'s and myeloproliferative disorders, hypereosinophilic syndrome and leukemoid
reaction, metastatic cancer and hepatocellular cancer, liver or renal failure.23 Inherited conditions like Spastic paraplegia and beta thalassemia have been found to mask vitamin B12 deficiency.24
Acute myeloid leukemia (AML) (64.5%) was the most common underlying disease, followed by acute leukemoid
leukemia (16.5%), lymphoma (11.8%), and others (multiple myeloma, myelodysplastic syndrome, chronic myeloid leukemia, and aplastic anemia) (7.2%).
In the CBC, leukocytes averaged 18,488, ranging between 3300 and 74,300 (SD 13,925), 39% of neutrophils, ranging between 11% and 90% (SD 18), 49% of lymphocytes, ranging between 8% and 84% (SD 18), 9.8 g/dl of hemoglobin, ranging between 2 and 16 g (SD 3), 496,842 platelets, ranging between 18,400 and 937,000 (SD 181,723), with leukemoid
reaction (24%) and eosinophilia (6%).
Patient B was found to have negative blood cultures at the time of presentation and his elevated WBC count more likely represents a leukemoid
reactions resulting from systemic infection can result in blasts, or other immature forms, being seen on the peripheral smear.
response was ruled out in this patient because of a lack of heterophil toxicity and no specific site of inflammation, infection, or neoplasia.
(4) Patients have a 90% incidence of leukemoid
reactions with white blood cell counts sometimes exceeding 100,000/[micro]L.
Increased transcobalamin I in a leukemoid
Clinical laboratory findings in three of the patients included leukemoid
reaction in all three, hemoconcentration in two, and thrombocytopenia in two.