Adhesion Deficiency-I (LAD-I) is a rare, life-threatening, autosomal recessive pediatric disease caused by a mutation of the ITGB2 gene that encodes for the Beta-2 Integrin component CD18.
Orally Active Small Molecule with Anti-Inflammatory Effect due to Suppression of Infiltration by Leukocytes
into Inflamed Sites
It should also be kept in mind that the lack of standard PRP preparation technique and the absence of platelet and leukocyte
concentration may still affect the results.
Investigations revealed haemoglobin concentration of 8.5 g/dl, platelet count of 556,000/mm3 markedly raised leukocyte
count of 54000/mm3 (neutrophils 80%, lymphocytes 13%, and monocytes 7%).
12%), and urine detection of leukocyte
esterase (87% vs.
As a class project at the University of Hawaii (with consent of participants), we tracked changes in microscopic leukocyte
differential counts and cellular morphology in an EDTA sample that was kept at room temperature.
Conclusion: Raised leukocyte
count was found to have high sensitivity but low specificity for diagnosing acute appendicitis.
In this study, we demonstrated that it was possible to perform SPECT/CT with [sup.111]In-labelled autologous leukocytes
almost 24 hrs after euthanasia with the same detectability of the osteomyelitic lesions as in the living pigs (78% versus 79%) by a simple count of [sup.111]In-labelled leukocyte
accumulation in the osteomyelitic bone lesions seen on CT.
It has been hypothesized that activation of NF-[kappa]B could represent a key regulator in epithelium-endothelium crosstalk able to induce leukocyte
extravasation into mucosal tissues during inflammation.
To study microvascular inflammation, we assessed sepsis-induced leukocyte
and platelet adhesion in small intestinal microcirculation of SIRT2KO and SIRT2KI mice compared to those of WT control.
Effects of three different types of exercise on blood leukocyte
count during and following exercise.
 In our study, the injection of carrageenan led to a significant increase in the leukocyte
count and fluid extravasation in the pleural cavity triggering a typical inflammatory reaction, which can be measured easily.