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Defective skin pigmentation, especially the congenital absence of pigment in patches or bands.



a disorder of the pigmentation of the skin manifested by a decrease in or complete loss of pigment.

Leukoderma can develop from previous skin lesions (seborrheic eczema, psoriasis, parapsoriasis, lichen ruber, pityriasis versicolor) or from certain medications (Chrysorabin, Psoriasin, pyrogallol), or as a symptom of a systemic disease (for example, secondary syphilis). It is characterized by the appearance on the skin of round depigmented spots of various size surrounded by hyperpigmentation. Syphilitic leukoderma develops three to six months after infection with syphilis and concentrates mainly on the posterolateral surface of the neck (less commonly, on the back, abdomen, and lateral surface of the chest). Leukoderma patients have no subjective sensations associated with the disease. Treatment is directed at the primary condition.


Mnogotomnoe rukovodstvo po dermato-venerologii, vols. 1–3. Moscow, 1959–64.
Mashkilleison, L. N. Chastnaia dermatologiia. Moscow, 1965.


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