leukotriene


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leukotriene

[‚lü·kō′trī‚ēn]
(biochemistry)
Any of a family of oxidized metabolites of certain polyunsaturated fatty acids, predominantly arachidonic acid, that mediate responses in allergic reactions and inflammations, produced in specific cells upon stimulation.
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Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction.
In conclusion, our pilot project found that a panel comprised of seven urinary biomarkers (8-hydroxyguanosine, dodecanal, leukotriene [C.sub.4], [alpha]1-antitrypsin, IgA-uromodulin complex, galactose-deficient IgA1, and heparan sulfate) differentiated patients with IgAN from patients with other renal diseases and healthy controls.
The CysLT1receptor antagonist montelukast blocks bronchoconstriction induced by inhaled leukotriene E4 in subjects with asthma.
The researchers landed on their breakthrough after discovering that inflammatory molecules known as leukotrienes are deregulated in Alzheimer's disease and related dementias.
Some asthma agents, such as montelukast, act as either leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists.
Recently, Hoxha and colleagues try to delineate the potential role of montelukast, the most described leukotriene receptor antagonist, in the treatment of cardiovascular diseases.
The meta-analysis uncovered a significant association between omega-3 supplementation in reduction in thromboxane B2 in the blood of participants at high risk of cardiovascular disease and in leukotriene B4 in the neutrophils of unhealthy subjects.
[16-20] Since inhaled or oral corticosteroids have not been shown to attenuate leukotriene production in vivo [21], therefore, a leukotriene receptor antagonist in combination with inhaled corticosteroid may confer additional benefits and could be the best combination.
Animal studies suggest that the marked increase in leukotriene levels occurring during aspirin desensitization may play a role.
We have previously found that montelukast, primarily a cysteinyl leukotriene (CysLTj) receptor antagonist, exhibited secondary, neutrophil-directed anti-inflammatory properties, which appeared to be cAMP-mediated [26].