Asthma medications comprise several drug classes, including leukotriene
antagonists and steroid-based inhalers.
An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene
and treatment for asthma.
This causes competitive inhibition of leukotrienes
which subsequently blocks the inflammatory effects of leukotrienes
Effects of anti leukotrienes
in the treatment of asthma.
10] Patients were excluded if they had significant co-morbidities, were receiving oral corticosteroids, LABAs, leukotriene
antagonists or theophylline or had undergone an asthma exacerbation or lower respiratory tract infection within the four weeks prior to study entry.
The lead antibody, binding to and neutralising several different leukotriene
isoforms, has demonstrated promising in-vivo data, and testing in animal models of respiratory disease, including asthma, is ongoing.
Mast cells coated by IgE are sensitized and later exposed to the same antigen, resulting in degranulation and secretion of leukotriene
(LTC4 and LTD4) and histamine, which act on the surrounding tissues.
block one specific trigger," he explains.
ALOX5 is an enzyme present in many inflammatory cells that makes inflammatory proteins called leukotrienes
By studying heart valves from patients undergoing surgery for various valve diseases, the researchers have shown that immune cells and a group of inflammatory substances called leukotrienes
can be found in calcified heart valves.
Inflammatory cells secrete proinflammatory mediators and chemotactic agents such as leukotrienes
(LT), tumoral necrosis factor (TNF), complement factor C5a, and interleukin 8 (IL-8) (3, 4, 6).
were measured at baseline and after 4 weeks.