levodopa


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Related to levodopa: carbidopa, dopamine, Sinemet

levodopa:

see l-dopal-dopa
, drug used to alleviate some of the symptoms of Parkinson's disease, particularly trembling, rigidity, and slow movements; the drug is also called levodopa. Parkinson's disease results when the concentration of dopamine in the brain is depleted (see catecholamine).
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levodopa

[¦lev·ə¦dō·pə]
(pharmacology)
C9H11NO4 Crystals or crystalline powder, soluble in dilute hydrochloric acid and in formic acid; used as an anticholinergic drug and in the treatment of Parkinson's disease. AbbreviatedL-dopa.
References in periodicals archive ?
Ja Lim [32] descreve uma reducao na eficiencia da degluticao apos a medicacao, na meta-analise realizada por Menezes e Melo [36], concluiu-se que a Levodopa nao melhora a disfagia na DP.
These drugs also are considered first-line drug therapy for PD along with levodopa (PDE 2010c).
The levodopa group, however, reported significantly greater symptomatic relief on the Unified Parkinson's Disease Rating Scale (UP-DRS) sections I, II, and III; Clinical Global Impressions severity and improvement ratings; and the Patient Global Impressions improvement scale.
A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. 056 Study Group.
Monoamine oxidase-B (MAO-B) inhibitors have also been shown to prevent the breakdown of levodopa. (1) As such, MAO-B inhibitors prolong the local effects of dopamine at CNS synapses.
MAOB (monoamine oxidase type B) inhibitors reduce the breakdown of dopamine in the brain and COMT (catechol-O-methyltransferase) inhibitors reduce the brain's ability to breakdown levodopa.
YOPD patients benefit from understanding the concept of "therapeutic window" of levodopa as soon as it is initiated.
They also found that the use of selegiline delayed the need for levodopa.
He added that the findings imply that patients being treated with levodopa should ask their neurologists to monitor the level of homocysteine in their blood, particularly if they are at risk for heart disease.
Since the discovery of levodopa, the prognosis for Parkinson's has changed dramatically.
The dopamine agonist pramipexole staved off three motor complications longer than levodopa in a double-blind, placebo-controlled trial in patients with early Parkinson's disease, according to Dr.
This drug however must be given parenterally and an alternative is to use levodopa. A levodopa test has been used [5, 6] in patients with fluctuations and dyskinesias, but not as an initial diagnostic tool.