Ja Lim  descreve uma reducao na eficiencia da degluticao apos a medicacao, na meta-analise realizada por Menezes e Melo , concluiu-se que a Levodopa
nao melhora a disfagia na DP.
These drugs also are considered first-line drug therapy for PD along with levodopa
group, however, reported significantly greater symptomatic relief on the Unified Parkinson's Disease Rating Scale (UP-DRS) sections I, II, and III; Clinical Global Impressions severity and improvement ratings; and the Patient Global Impressions improvement scale.
A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
. 056 Study Group.
Monoamine oxidase-B (MAO-B) inhibitors have also been shown to prevent the breakdown of levodopa
. (1) As such, MAO-B inhibitors prolong the local effects of dopamine at CNS synapses.
MAOB (monoamine oxidase type B) inhibitors reduce the breakdown of dopamine in the brain and COMT (catechol-O-methyltransferase) inhibitors reduce the brain's ability to breakdown levodopa
YOPD patients benefit from understanding the concept of "therapeutic window" of levodopa
as soon as it is initiated.
They also found that the use of selegiline delayed the need for levodopa
He added that the findings imply that patients being treated with levodopa
should ask their neurologists to monitor the level of homocysteine in their blood, particularly if they are at risk for heart disease.
Since the discovery of levodopa
, the prognosis for Parkinson's has changed dramatically.
The dopamine agonist pramipexole staved off three motor complications longer than levodopa
in a double-blind, placebo-controlled trial in patients with early Parkinson's disease, according to Dr.
This drug however must be given parenterally and an alternative is to use levodopa
. A levodopa
test has been used [5, 6] in patients with fluctuations and dyskinesias, but not as an initial diagnostic tool.