Amyloidosis

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Related to lichen amyloidosis: lichen planus, macular amyloidosis

amyloidosis

[‚am·ə·loi′dō·səs]
(medicine)
Deposition of amyloid in one or more organs of the body.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Amyloidosis

 

or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.

V. V. SEROV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Hyperkeratosis and acanthosis were more prominent in lichen amyloidosis compared to macular amyloidosis.
Increased basal layer pigmentation was seen in 33.3% macular amyloidosis cases but only in 3.1% lichen amyloidosis. Among the macular amyloidosis cases of Mysore V et al, basal layer pigmentation was seen in 80% subjects.
From these observations, it may be added that besides the size of amyloid deposition, prominent hyperkeratosis, acanthosis and papillomatosis, other features like increased basal layer pigmentation and pigment incontinence (both more frequent in macular amyloidosis) as well as papillomatosis and periappendageal mononuclear and neutrophilic dermal infiltrate (more frequent in lichen amyloidosis) can be used for distinction between the two histologically.
Lichen amyloidosis. Histochemical and electron microscopic studies.
Lichen amyloidosis of the auricular concha: Successful treatment with electrodessication.
A case of lichen amyloidosis treated with pulsed dye laser.
Frolich M, Enk A, Diepgen TL, Weisshaar E.Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol.
Parsi K, Kossard S.Thermosensitive lichen amyloidosis. Int J Dermatol 2004; 43: 925-8.