2015;7 (s1) (7th International Symposium on Clinical Applications of Free Light Chains
and Heavy/light Chain
They are usually composed of nonamyloid light chains
(typically [kappa]), which means that the light chain
fragments do not form fibrils and electron microscopy shows a granular material.
Although the use of two separate vectors for the expression of heavy chain and light chain
has been reported, this approach has serious shortcomings such as the possibility of the integration of the two vectors in different genomic sites and the variation of the copy number for each gene which can in turn cause an improper ratio of the expressed light chain
to heavy chain, and reduce the possibility of achieving cell clones with high expression level of active antibody.
The authors relied on the proportion of the abnormal light chain
to calculate the concentration of the intact monoclonal immunoglobulin based on the total IgG using nephelometry.
Extended use of serum free light chain
as a biomarker in lymphoproliferative disorders: a comprehensive review.
Palladini, "Systemic light chain
amyloidosis: an update for treating physicians," Blood, vol.
In view of the amyloid deposit on the lip and evidence of peripheral neuropathy with raised serum free light chains
, investigations were directed to search for systemic amyloidosis.
Keywords: Fragment C, Light chain
, Monoclonal antibody, Tetanus toxin
15) Improved survival among patients with non-secretory myeloma following autologous stem cell transplant in comparison to patients with IgG, IgA, and light chain
subtypes has also been reported.
The myosin molecule has the IQ motif sequence in the neck for binding the light chain
, (16) but the IQ motif is a calmodulin binding site in the [Ca.
Both asthma and rhinitis patients have elevated free light chain
levels, according to three studies cited by the Dutch researchers.
Signaling pathways involved in the assembly, disassembly, and maintenance of TJ are controlled by a number of signaling molecules, such as protein kinase C, mitogen-activated protein kinases, myosin light chain
kinase, and Rho GTPases.