Interestingly, it was noted during evaluation that some laboratories reported a limit of detection
well below the generally accepted sensitivity for the technology they were using.
001% NBA post-stained DNA gel gave observable bands after staining for three hours and was estimated to give a limit of detection
of about 30 ng DNA.
Sensitivity is not interchangeable with limit of detection
Sensitivity is sometimes used to refer to the limit of detection
, but this use is not generally approved.
P/B is a critical term in determining the limit of detection
The urine-based KRAS oncogene mutation assay, intended to detect the seven most common mutations of the KRAS oncogene, namely six in codon 12 and one in codon 13 of exon 1, has achieved a reproducible lower limit of detection
(LLOD) of 0.
The lower limit of detection
and quantification of the quantitative HCV viral load assay is 15IU/mL against current qualitative HCV assays with 10-50 IU/mL.
5 M) and limit of detection
at approximately 1 [micro] M.
Laboratory data in environmental and biomedical studies are frequently constrained by a lower limit of detection
(LOD); however, multiple imputation (MI) methods can provide valid and robust parameter estimates, as well as explicit imputed values, that can be used as variables in subsequent statistical analyses.
BrdU incorporation was highly correlated with the concentration of SEA and can detect 20 picograms per ml of SEA, a limit of detection
far lower than that reported for most assays.
The new validation package enables users to test specifications including background noise, background spike, lower limit of detection
, crosstalk, linearity, relative luminescence units (RLU), well-to-well precision, left-to-right bias, top-to-bottom bias, and kinetic noise, spike, and drift in the low and high signal ranges.