For further analysis only questionnaires of women with lipodystrophy
were selected (50 questionnaires).
The most discussed clinical disease associated with seipin loss-of-function disorders is type 2 Berardinelli-Seip congenital lipodystrophy
(BSCL type 2).
Observation and palpation techniques were used in assessing lipodystrophy
in these diabetics .
A total of 13 patients with generalized lipodystrophies (12 patients with CGL: 7 patients with CGL1, 3 patients with CGL2, and 2 patients with CGL4; and 1 patient with AGL) and 19 patients with partial lipodystrophy
(12 patients with FPLD and 7 patients with APL) were included between September 2013 and December 2015.
, acanthosis nigricans, muscular hypertrophy, hirsutism, hepatomegaly, and fatty liver were features in all three patients (Figure 1).
(iii) mixed lipodystrophy
: presence of signs of both lipoatrophy and lipohypertrophy.
In terms of metabolic profile, no statistical difference was found between lipodystrophy
subtypes (Table 6).
is a syndrome associated with the use of antiretroviral therapy, characterized by dyslipidemia, increased cholesterol and triglyceride, increased glycemia associated with insulin resistance and changes in redistribution of body fat.
in 2012, include early disease onset, recurrent febrile episodes, skin lesions--including recurrent attacks of erythematous annular plaques and violaceous swelling of the eyelids, delayed physical development, progressive lipodystrophy
, arthralgias, systemic inflammation, and aseptic meningitis episodes.
Klein, the senior attorney and AIDS Law Project director at the Boston-based Gay & Lesbian Advocates & Defenders, had been doing appeals for lipodystrophy
sufferers like Fullem.
However, recent reports suggest increased rates of cardiovascular risk, (1,2) body fat changes (lipodystrophy
), (3) and long-term adverse effects such as changes in physical functioning, disabilities and health-related quality of life (HRQOL) are common findings in this population.
Global Markets Direct's, 'Lipodystrophy
- Pipeline Review, H2 2015', provides an overview of the Lipodystrophy
's therapeutic pipeline.