lipoic acid


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Related to lipoic acid: Alpha lipoic acid

lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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.

Lipoic Acid

 

6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
(biochemistry)
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
* By helping to reduce weight, and improve blood sugar control and blood lipid profiles, lipoic acid supplementation can help reduce the risk for premature aging and disease.
Quercetin and lipoic acid pretreatment of Al[Cl.sub.3] exposed rats restored the altered superoxide dismutase to normal levels.
A study of the antioxidant effect of alpha lipoic acids on sperm quality.
After four years, tests showed less severe neuropathy (largely due to less muscular weakness) in the lipoic acid takers, who also reported less weakness but no less pain, burning, or other symptoms.
Anti-obesity and lipid- lowering properties of alpha- lipoic acid. J.
Dietary alpha lipoic acid improves body composition, meat quality and decreases collagen content in muscle of broiler chickens.
"Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury"; Brain Injury, 2014; 1 DOI: 10.3109/02699052.2014.973448
Researchers fed laboratory animals higher levels of lipoic acid than might be attained in a normal diet, while monitoring proteins known to be affected by disruption of the circadian clock in the older animals.
Additional chol + vitD-fed rabbits were given 0.12 mmol x [kg.sup.-1] x [day.sup.-1] lipoic acid (n = 11) or 0.1 mmol x [kg.sup.-1] x [day.sup.1] tempol (n = 15) in drinking water.
Dai et al., "Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation," European Journal of Pharmacology, vol.
Contributed by pharmaceutics, pathology, cancer, nutrition, and other specialists from North America and Asia, chapters address the basic mechanisms of inflammation/oxidative stress-driven cancer, including preventing carcinogenesis, the role of obesity, and antioxidant properties of common dietary phytochemicals; cellular signal transduction, molecular targets, and biomarkers of these cancer-preventive phytochemicals; challenges with in vivo absorption and pharmacokinetics of phytochemicals; cancer prevention and vitamins A, D, and E, omega-3 and omega-6 fatty acids, flavonoids and polyphenols, garlic organosulfur compounds and crucifer glucusinolates, and selenium, herbal medicines, and alpha lipoic acid; and epigenetics and chronic inflammation.