lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.
Researchers (some with industry ties) randomly assigned 456 diabetic neuropathy patients to take 600 milligrams of lipoic acid or a placebo every day.
Lipoic acid - biological activity and therapeutic potential.
Dietary alpha lipoic acid improves body composition, meat quality and decreases collagen content in muscle of broiler chickens.
Lipoic acid is already used in the treatment of degenerative diseases such as multiple sclerosis and diabetic neuropathy.
This could be a breakthrough in our understanding of why lipoic acid is so important and how it functions," said Tory Hagen, a professor at the Oregon State University in the US, said the study appeared in the journal Biochemical and Biophysical Research Communications.
Note to Editor: A sample of the Alpha Lipoic Acid, Vitamin C Ester & DMAE Cream can be mailed to the Editor directly from Reviva Labs.
Effects of alpha lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
Although the symptomatology of these disorders varies, all are noted to respond favorably to nutritional intervention, specifically that of antioxidants, including CoQio, alpha lipoic acid, acetyl-1-carnitine and N-acetyl cysteine (NAC).
ABSTRACT: Alpha lipoic acid finds extensive use as a dietary supplement, as an alternative medicine in treatment of diabetes mellitus, hypertension, hyperglycemia, oxidative stress, and for many other symptoms.
com This lightweight formula contains a unique blend of ingredients, including alpha lipoic acid and vitamin C ester.