lipoic acid

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Related to lipoic acid: Alpha lipoic acid

lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
Dietary alpha lipoic acid improves body composition, meat quality and decreases collagen content in muscle of broiler chickens.
5) Vitamin C regenerates vitamins D and E, lipoic acid, CoQ10, and L-carnitine.
Researchers fed laboratory animals higher levels of lipoic acid than might be attained in a normal diet, while monitoring proteins known to be affected by disruption of the circadian clock in the older animals.
Fortunately, you don't need to wait for Big Pharma to develop a synthetic, costly version of lipoic acid in order to combat mitochondrial dysfunction.
Researchers have been studying the potential of lipoic acid to "turn off" the immune attack in mice with the MS-like disease known as experimental allergic encephalomyelitis or EAE.
Alpha Lipoic Acid along with the herbs and homeopathic remedy keeps the problem from becoming bad.
Hagen has pioneered the study of lipoic acid and ALCAR, along with biochemistry professor Bruce Ames, Ph.
15) The individuals were given 600 mg of racemic alpha lipoic acid once daily for an average period of 337 [+ or -] 80 days.
While experimenting on rats, the researchers found that supplements of lipoic acid lowered triglyceride levels up to 60 percent.
5 g Polygonum cuspidatum standardised to 15 mg resveratrol, 96 mg citrus bioflavonoids, 96 mg hesperidin, 96 mg rutin, 48 mg quercetin and 50 mg lipoic acid.
Brian Day, National Jewish Medical and Research Center, to test the ability of lipoic acid, dihydrolipoic acid, and thioredoxin to reverse or prevent pulmonary injury caused by sulfur mustard
Favourite products Perricone Alpha Lipoic Acid Face Firming Activator (pounds 110, 020 7329 2000), Dermalogica Dermal Clay Cleanser (pounds 18.