2005), such as suppressed cholesterol absorption, increased cholesterol secretion through biliary excretion, induced differentiation of the human erythroleukemia cell line by changing lipooxygenase
activity, induced apoptosis, and cell cycle arrest in human osteosarcoma cell line, it has estrogenic effects (Aradhana Rao and Kale, 1992), as well shows antitumor activity (Moalic et al.
Cyclooxygenase and lipooxygenase
inhibitors have been reported from onions (Bayer et al.
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase
, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.
Lichochalone A is a COX as well as a lipooxygenase
inhibitor, also allowing for anti-inflammatory effects.
In addition to this, CAPE is a lipooxygenase
inhibitor with antioxidant properties (Natarajan et al.
modulation to reserve carcinogenesis.
The result of the decrease in arachidonic acid for eicosanoid formation and competition with the n-3 FAs for the cyclooxygenase and lipooxygenase
enzyme sites generally results in decreased production of the 2-series prostanoids, such as thromboxane A2 (TXA2) and prostaglandin E2.
Other arachidonic metabolites are formed via the lipooxygenase
and cycloxygenase pathways and cause amplification of the inflammatory response and increased vascular permeability.
Low antioxidant levels tied to higher levels of some inflammatory cytokines * Cruciferous vegetables (Allium vegetables (broccoli, release sulfur- cauliflower, Brussels containing sprouts) compounds which * Citrus fruits alter platelet * Black teas aggregation and * Allium vegetables lipid metabolism) (onions, garlic) Spices containing * Ginger * Inhibits cyclo- particular and lipooxygenase
antiinflammatory pathways chemical compounds * Rosemary * Rosmarinic acid in rosemary decreases inflammatory cytokines, chemokines, and allergen-specific antibody * Turmeric * Curcumin from turmeric suppresses COX-2 expression * Oregano * Contains compounds with antimicrobial, antioxidant antimutagenic properties.
The synthetic estrogen DES is oxidized to DES quinone to yield ROS by hydroperoxidase activity of lipooxygenase
, which might be associated with the toxic effect of this synthetic estrogen (Nunez-Delicado et al.
This may be mediated through cyclooxygenase and lipooxygenase
products of arachidonic acid.
Antiinflammatory activity is related to glucocorticosteroids ability to inhibit phospholipase A2, cyclooxygenase and lipooxygenase
pathways, thereby limiting the release of arachidonic acid and its metabolites.