Gal-3 = Galectin 3, LPS = lipopolysaccharide, LOS = lipooligosaccharides, PI mannosides = phosphatidylinositol mannosides, LPG = lipophosphoglycan
, GlcNac = N- acetylglucosamine, E.
A tetrasaccharide antigen found on the lipophosphoglycan
membrane of the genus Leishmania may be explored using a synthetic carbohydrate-based vaccine for the treatment of leishmaniasis .
Desjardins, "Leishmania promastigotes require lipophosphoglycan
to actively modulate the fusion properties of phagosomes at an early step of phagocytosis," Cellular Microbiology, vol.
(LPG), the major identified ligand from these parasites, has been reported to induce inflammation through TLR2 and 4.
Turco et al., "A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan
," Journal of Experimental Medicine, vol.
The interaction between parasite and the vector midgut cells is controlled by species-specific modifications of the major surface glycoconjugate of promastigotes, lipophosphoglycan
(LPG), which selectively binds to the midgut galectin receptor [7,11,12].
The mature infective metacyclic promastigotes have surface glycosyl inositol phospholipid (GIPL) and lipophosphoglycan
(LPG), virulence factors which inhibit the action of the complement system.
Leishmania produces a range of glycoconjugates containing phosphoglycan (PG) and two of the most studied abundant surface constituents are the GPI-anchored molecules lipophosphoglycan
(LPG) and GP63 zinc metalloprotease (4) that play important roles in parasite survival and pathogenecity (5).
Leishmania major survival in selective Phlebotomus papatasi sandfly vector requires a specific SCG-encoded lipophosphoglycan
Epitope mapping of monoclonal antibodies directed against lipophosphoglycan
of Leishmania major promastigotes.
major infection, it is well-documented that Leishmania lipophosphoglycan
is opsonized by C3bi .