lipoplex

Also found in: Medical.

lipoplex

[′līp·ə‚pleks]

(medicine)

A deoxyribonucleic acid-liposome complex used as a gene delivery vehicle in nonviral gene therapy.

References in periodicals archive ?

Figure 3(c) shows the high-magnification image of the lipoplex formed from the metallosurfactant complexation with DNA and Figure 3(d) shows the size of the lipoplex to be ~75 nm based on the height profile of the AFM cantilever.

Alkyl Length Effects on the DNA Transport Properties of Cu (II) and Zn(II) Metallovesicles: An In Vitro and In Vivo Study

To date, numerous nonviral transfection carriers based on cationic lipids and cationic polymers are available on the market (lipoplexes and polyplexes, resp.).

Magnetic nanoparticle based nonviral microRNA delivery into freshly isolated [CD105.sup.+] hMSCs

To our knowledge, no detailed reports have so far been published regarding lipoplex and polyplex-mediated transfection of DNA into different myeloma cell lines.

Optimization of gene transfection in murine myeloma cell lines using different transfection reagents

Cationic liposomes The presence of HA-DOPE lipid [19-21] conjugate in the liposome composition did not affect the lipoplex formation.

Lipid-based nanovectors for targeting of CD44-overexpressing tumor cells

Hashida, "Enhanced DNA vaccine potency by mannosylated lipoplex after intraperitoneal administration," Journal of Gene Medicine, vol.

Targeting antigens to dendritic cell receptors for vaccine development

Moreover, the encapsulation of CpG ODNs in lipidic particles (i.e., liposomes, lipoplexes, etc.) results in increased immunostimulatory effects [70].

Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma

Dufay-Wojcicki et al., "Lipoplexes targeting the CD44 hyaluronic acid receptor for efficient transfection of breast cancer cells," Molecular Pharmaceutics, vol.

Identification of a Novel Anticancer Oligopeptide from Perilla frutescens (L.) Britt. and Its Enhanced Anticancer Effect by Targeted Nanoparticles In Vitro

This was demonstrated in lung cancer models for delivering miR-29b through cationic lipoplexes. miR-29b is a tumor suppressor that is downregulated in cancer.

The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics

Lee, "MicroRNA delivery by cationic lipoplexes for lung cancer therapy," Molecular Pharmaceutics, vol.

The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer

Lipoplexes were then prepared by complexation with a luciferase expressing plasmid (pCMV-luc).

Transfection Studies with Colloidal Systems Containing Highly Purified Bipolar Tetraether Lipids from Sulfolobus acidocaldarius

Commercially available cationic lipoplexes and polyplexes such as the Superfect reagent and lipofection are valued for their limited toxicity, ease of use and ability to transfect a wide range of cell types with relatively higher efficiencies than seen with previously mentioned methods (10), (32).

Non-viral transfection methods optimized for gene delivery to a lung cancer cell line

Miller, "A dialkynoyl analogue of DOPE improves gene transfer of lower-charged, cationic lipoplexes," Organic and Biomolecular Chemistry, vol.