Common statins are Lipitor, Lescol, Lipostat
, Zocor and Crestor.
The positional cloning of the obese (ob) gene (16) and the subsequent preparation of its encoded product, leptin (19), has provided a renewed stimulus for research into obesity suggesting that leptin, a 16 kilodalton protein, may act as a sensing hormone, or "lipostat
," responding to the mass of adipose tissue in a feedback loop between adipose tissue and leptin receptors in the hypothalamus.
When this protein crosses the blood-brain barrier, it provides the brain with information about the body's fat deposits, and thus acts as a part of the feedback mechanism that can function as a lipostat
Some suggested that leptin influenced the hedonic perception of food, and that, as a lipostat
, it was part of a natural system that attempts to maintain total body adiposity within a stable range.
Over 50 years ago Kennedy (1953) formulated the 'set point' hypothesis which was that for any individual there was a preset level of fat storage in the body regulated by a 'lipostat
The traditional idea of a 'set point' (Mrosovsky and Powley, 1977) by which energy balance is monitored through some negative feedback loop to correct feeding behaviour, has been recently advanced by the discovery of leptin and the development of the lipostat
. Readers are referred to a detailed account by Speakman (2003).