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An enzyme catalyzing the oxidation of the double bonds of an unsaturated fatty acid.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



an enzyme of the oxydoreductase class that oxidizes unsaturated fatty acids to peroxides.

Lipoxidase was first discovered in 1934 in soybeans. It was later found to exist in the seeds of other plants and in the muscle tissue of fish and mammals. The principal substrates for lipoxygenase are linoleic, linolenic, and arachidonic acids and their respective esters. Lipoxidase is activated by polypeptides.


Kretovich, V. L. Vvedenie v enzimologiiu. Moscow, 1967.
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Adrian, "Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway," Molecular Cancer Therapeutics, vol.
Varfolomeev, "Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties," FEBS Letters, vol.
Dobrian et al., "Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats," American Journal of Physiology, vol.
While specific inhibition of COX-2 with celecoxib alone was sufficient to cause increased utilization of arachidonate by the lipoxygenase pathway, increases of LTB4 production were even greater in the presence of indomethacin, suggesting that the inhibition of both COX-1 and COX-2 provided more arachidonate substrate for metabolism by the lipoxygenase pathway.
The [F.sub.2] and [F.sub.3] plants were grown in Costa Rica, and [F.sub.3] plants were identified which were null for lipoxygenases 2 and 3.
Stereospecific inhibition of PGHZ induced platelet aggregation by lipoxygenase products of icosaenoic acids.
(6.) Joseph Van Waesberghe asked the question 'Is it worth the effort to do Lipoxygenase research on barley and malt?' (7.) Godfrey Palmer of the International Centre for Brewing and Distilling at Heriot Watt University delivered the keynote address, a discussion of the future of cereal science and malting technology.
All the compounds were evaluated for their lipoxygenase inhibitory potential.
Several investigators have pharmacologically tested the effect of lipoxygenase inhibitors on ischemic injury [125]; however, since results are controversial, a number of transgenic mice were studied to overcome the limitation of unspecific responses by pharmacological agents.
(2013) Lipoxygenase and urease inhibition of the aerial parts of the Polygonatumverticillatum.
The present work investigated the possible protective effect of baicalein, a natural lipoxygenase enzyme inhibitor, on both insulin deficiency (ID) and insulin resistance (IR)-induced macro-vascular impairment.