Hurley described another big advantage of the investigational vaccine, in addition to its almost-too-good-to-be-true efficacy: the fact that, unlike Zostavax, it's not a live-virus vaccine
. That means it doesn't require freezer storage, thereby removing a major impediment to convenient vaccination.
A potential solution to the challenge of developing a safe live-virus vaccine
for HCMV is to use recombinant technologies to engineer attenuated vaccines that, by virtue of targeted removal of genes that contribute to immune modulation and/or pathogenesis in vivo, could in principle retain immunogenicity while avoiding potential risks.
Health professionals have always known of an inherent risk of polio from live-virus vaccine
. Between 1983 and 1991, every dose of oral vaccine manufactured in the United States failed to meet safety standards.
It is interesting that differences on the levels of IgG antibodies to BRSV were found for Balb/C and C57BL/6 mice when using both Quil A and Live-virus vaccine
Jonas Salk produced an injectable, killed-virus vaccine; Albert Sabin promoted an oral, live-virus vaccine
. The two men headed camps that debated the choice, sometimes bitterly.
The FDA has not approved this live-virus vaccine
for use in pregnant women and immunocompromised persons, including transplant recipients and persons receiving corticosteroid therapy.
A: Simple, says Thomas Mack: "This is the single most dangerous live-virus vaccine
we have." Vaccines for flu and other viral diseases are typically made from weakened or killed disease-causing particles.
Because the immune systems of HIV-positive people may not be able to fight off the effects of active pathogens, doctors say they should never get a live-virus vaccine
This live-virus vaccine
may be given any time after the first birthday.
ACAM2000 is a live-virus vaccine
indicated for active immunization against smallpox.
He advises waiting 2 years before immunizing patients with live vaccines such as MMR--the only live-virus vaccine
shown to be safe for this patient group.
The currently licensed smallpox vaccine is a live-virus vaccine
related to smallpox (Variola) virus; there is no smallpox virus in the vaccine.