Amyloidosis

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Related to localized amyloidosis: cutaneous amyloidosis

amyloidosis

[‚am·ə·loi′dō·səs]
(medicine)
Deposition of amyloid in one or more organs of the body.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Amyloidosis

 

or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.

V. V. SEROV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Localized amyloidosis of the ureter usually is benign and typically carries a good prognosis.
Primary Localized Amyloidosis of the Bladder: Experience with Dimethyl Sulfoxide Therapy.
However, as localized amyloidosis has been seen to recur, either locally or in a multi-focal manner, and rarely as a systemic disease, a surveillance programme must be recommended.
AL amyloid is the material found in most cases of primary localized amyloidosis of the urinary tract.
Localized amyloidosis is usually associated with the AL type of amyloid.
Primary localized amyloidosis of the urinary tract is a rare condition and most of the reported cases have involved the bladder.
Immunoglobulin lambda light chains are the precursors of ureteral localized amyloidosis: a micro-method for extraction of amyloid: amyloid.
We describe the case of a 41-year-old man who had localized amyloidosis that involved the external auditory canal and middle ear.
Although this "molecular-based" classification of amyloidoses is very precise and allows for future expansion to include additional amyloid types, a simpler subdivision into systemic versus localized amyloidosis would be more relevant to clinical practice.
Patients with localized amyloidosis have a considerably better prognosis than do those with systemic disease.
Localized amyloidosis of the larynx is uncommon, accounting for fewer than 1% of all benign laryngeal tumors.
Primary non-Hodgkin lymphoma of the breast is a rare disease, representing 0.04% to 0.53% of all primary malignant tumors of the breast and 2.2% of extranodal malignant lymphomas.[1] Primary malignant lymphoma of the mucosa-associated lymphoid tissue (MALT) involving the breast is even rarer.[2] Bilateral primary lymphomas of the breast are exceptional.[3] We describe a primary bilateral breast MALT lymphoma with bilateral atypical ductal hyperplasia and localized amyloidosis and its clinical, histologic, and immunohistochemical features in a patient with a previous history of systemic lupus erythematosus.

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